Supplementation of fenugreek leaves to diabetic rats. Effect on carbohydrate metabolic enzymes in diabetic liver and kidney.

Abstract

The present study was designed to evaluate the effect of supplementation of fenugreek leaves, an indigenous plant widely used in Indian Ayurvedic medicine for the treatment of diabetes mellitus, in streptozotocin induced diabetic rats. Supplementation of the diet with fenugreek leaves showed a significant effect on hyperglycaemia, hypoinsulinaemia and glycosylated haemoglobin in streptozotocin diabetic rats. Fenugreek leaves improved the body weight and liver glycogen. Fenugreek leaves also showed a significant effect on key carbohydrate metabolic enzymes in diabetic rats. The effect of fenugreek leaves was found to be similar to that of glibenclamide. Thus, fenugreek leaves exhibited antidiabetic action in streptozotocin-induced diabetic rats. Insulin restored all the parameters to near normal levels in diabetic rats.

• Authors: B Anitha Devi, N Kamalakkannan, P Stanely Mainzen Prince
• Journal: Phytotherapy research : PTR (Phytother Res) Vol. 17 Issue 10 Pg. 1231-3 (Dec 2003) ISSN: 0951-418X [Print] England
• PMID: 14669264 (Publication Type: Journal Article)
• Copyright: Copyright 2003 John Wiley & Sons, Ltd.

Chemical References

• Blood Glucose
• Glycated Hemoglobin A
• Hypoglycemic Agents
• Insulin
• Streptozocin
• Glycogen

Topics

• Animals
• Blood Glucose (metabolism)
• Diabetes Mellitus, Experimental (chemically induced, prevention & control)
• Dietary Supplements
• Female
• Glycated Hemoglobin (drug effects)
• Glycogen (metabolism)
• Hypoglycemic Agents (administration & dosage, pharmacology, therapeutic use)
• Insulin (blood)
• Liver (drug effects, metabolism)
• Phytotherapy
• Plant Leaves
• Rats
• Rats, Wistar
• Streptozocin
• Trigonella