[The antiviral activity of peptide immunomodulator "Gepon" in experimental infections caused by herpes simplex viruses types 1 and 2].

Abstract

Experimental data are reported on the antiviral activity of peptide immune-modulator "Gepon" in infections caused by herpes simplex virus (HSV), types 1 and 2, in vitro and in vivo. The drug proved to be non-toxic and did not possess any viricidal action. Its antiviral effect was registered in experiments with a multiple-infection cells' culture. The maximal effect was a 100-fold reduction of the viral titer when it was used in a concentration of 6.25 mcg/I as a preventive measure 24 hours before triggering the infection. The mentioned drug's effect was reliably higher than its use within a treatment scheme (1 hour after the infection onset). "Gepon" possessed the reliable protecting qualities (36% of protection with a mean increase of the infected mouse life by 1.9 days) in experiments with intraperitoneally infected mice (10 LD50/mouse of HSV, type 2), when the drug was administered in doses of 0.1 and 1 mcg/mouse.

• Authors: I F Barinskiĭ, L M Alimbarova, A A Lazarenko, R I Ataullakhanov
• Journal: Voprosy virusologii (Vopr Virusol) 2003 Sep-Oct Vol. 48 Issue 5 Pg. 30-3 ISSN: 0507-4088 [Print] Russia (Federation)
• Vernacular Title: Protivovirusnaia aktivnost' peptidnogo immunomoduliatora "Gepon" pri éksperimental'nykh infektsiiakh, vyzvannykh virusami prostogo gerpesa tipov 1 i 2.
• PMID: 14598478 (Publication Type: Journal Article)

Chemical References

• Adjuvants, Immunologic
• Antiviral Agents

Topics

• Adjuvants, Immunologic (therapeutic use, toxicity)
• Animals
• Antiviral Agents (therapeutic use, toxicity)
• Chlorocebus aethiops
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Herpes Simplex (drug therapy, prevention & control)
• Injections, Intraperitoneal
• Mice
• Simplexvirus (drug effects)
• Vero Cells