Abstract | BACKGROUND/AIMS: METHODOLOGY: 41 patients and 45 healthy control blood donors were included in this study. All subjects were Polish. RESULTS: The incidence of HLA DRB1*0103 was low (2.44%), but was associated with fulminant course of the disease (pancolitis with megacolon toxicum). None of the ethnically matched healthy control blood donors possessed the HLA DRB1*0103 allele (0.00%). CONCLUSIONS: The results gained in the presented study confirm, that in the Polish population HLA DRB1*0103 allele is uncommon and it would not be a useful marker of disease susceptibility.
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Authors | B Puzanowska, D Prokopowicz, S Ziarko, P Radziwon, T W Lapinski |
Journal | Hepato-gastroenterology
(Hepatogastroenterology)
2003 Sep-Oct
Vol. 50
Issue 53
Pg. 1436-8
ISSN: 0172-6390 [Print] Greece |
PMID | 14571756
(Publication Type: Journal Article)
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Chemical References |
- HLA-DR Antigens
- HLA-DRB1 Chains
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Topics |
- Adult
- Colitis, Ulcerative
(genetics)
- Female
- Genetic Predisposition to Disease
(epidemiology)
- HLA-DR Antigens
(genetics)
- HLA-DRB1 Chains
- Humans
- Male
- Poland
- Seroepidemiologic Studies
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