Histocompatibility Antigens Class II

Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.

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Networked: 1508 relevant articles (19 outcomes, 111 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ferrone, Soldano: 5 articles (03/2015 - 12/2005)
2.	Haque, Azizul: 5 articles (07/2014 - 02/2008)
3.	Krishnakumar, Subramanian: 5 articles (03/2004 - 08/2003)
4.	Abhyankar, Dhiraj: 5 articles (03/2004 - 08/2003)
5.	Biswas, Jyotirmay: 5 articles (03/2004 - 08/2003)
6.	van Luijn, Marvin M: 4 articles (06/2015 - 03/2010)
7.	Amria, Shereen: 3 articles (07/2014 - 02/2008)
8.	van de Loosdrecht, Arjan A: 3 articles (04/2011 - 03/2010)
9.	Chamuleau, Martine E D: 3 articles (04/2011 - 03/2010)
10.	Ossenkoppele, Gert J: 3 articles (04/2011 - 03/2010)

Related Diseases

1.	Infection 12/14/2005 - "Human leukocyte antigen class II DQB1*0301, DRB1*1101 alleles and spontaneous clearance of hepatitis C virus infection: a meta-analysis." 08/01/1998 - "Protection against ascending infection of the genital tract by Chlamydia trachomatis is associated with recruitment of major histocompatibility complex class II antigen-presenting cells into uterine tissue." 06/30/1997 - "Finally, increased expression of both, class I and class II major histocompatibility antigens was also observed in MVV-infected PAM on days 5 and 7, whereas SCPC only demonstrated upregulation of MHC class I. These results, indicative of an alteration of some cell functions in MVV-infected cells, may help to understand interactions between MVV-infected cells and bacteria in simultaneous infections and may provide clues to the possible in vivo interactions of both pathogens." 01/01/1989 - "Kinetic studies indicated that MHC class II antigen expression continues to increase three days after infection. " 12/01/1986 - "Since several reviews on the immunologic aspects in the OS model have been published in recent years we have in this communication attempted to discuss the - mostly still rudimentary - findings concerning the target organ itself, including morphological changes before the beginning of infiltration, the analysis of Tg, the altered thyroid function before onset of SAT, the results of cross-breeding studies of OS and inbred normal chickens in respect to the susceptibility of the offspring for the transfer of SAT, the possible role of a virus infection and the aberrant expression of MHC class II antigens on TEC. "
2.	Neoplasms (Cancer) 12/01/2002 - "Human leukocyte antigen class II and cervical cancer risk: a population-based study." 03/01/1992 - "[Immunohistological study on HLA class II antigen expression and lymphocyte infiltration in cancer tissues of the uterine cervix]." 01/01/1990 - "In most studies, baboon T-cell NHLs tumor cells belonged to activated T-cells because they expressed Ia-like antigens and IL2R at high levels. " 12/01/1985 - "These studies demonstrate a substantial difference between the Eb and ESb tumor lines with respect to: (i) constitutive expression of class II major histocompatibility antigens, and (ii) response to IFN-gamma treatment." 10/01/2015 - "Human leukocyte antigen class II DRB1*1302 allele protects against cervical cancer: At which step of multistage carcinogenesis?"
3.	Melanoma (Melanoma, Malignant) 09/01/1981 - "These results suggested that double staining of pigmented skin lesions with the MoAb 653.40S and with an MoAb to Ia-like antigens may help to solve controversial diagnosis of melanoma. " 01/01/2009 - "Insights into the Role of GILT in HLA Class II Antigen Processing and Presentation by Melanoma." 12/01/2008 - "In the responded non-injected lesions of this patient, histopathologically, infiltration of CD4 positive T cells was observed around the melanoma cells in the dermis, which expressed the HLA-Class II antigen. " 06/15/2006 - "This evidence was corroborated by the immunohistochemical analysis for HLA class II antigen expression of melanoma lesions from an unrelated group of 52 AJCC stage III and IV patients. " 12/01/2003 - "Expression of HLA class I, beta(2)-microglobulin and HLA class II antigens in primary orbital melanoma."
4.	Leukemia 07/01/1996 - "Three patients received PBSCT from family donors mismatched for one class II antigen: all engrafted, one developed grade I aGVHD; one died of leukemia on day +155; two are alive disease free 267 to 290 days postgraft. " 03/01/1989 - "Differential expression of MHC class II antigens in myelomonocytic leukemia cell lines." 01/01/1986 - "These data illustrate that infants with ALL have extensive and bulky disease more often than do older children and are more often affected with a prognostically unfavorable phenotype of acute leukemia (AL) which expresses Ia-like antigens but is more often PAS- and CALLA-. " 10/15/1985 - "Heterogeneity of Ia antigen expression by proliferating nonlymphocytic leukemia blast cells." 04/01/1984 - "As detected by VIC-Y1 and in the limits of our assays, gamma-chains could not be found at the cell surface; their tissue distribution, determined by cytoplasmic indirect immunofluorescence with VIC-Y1, closely resembles that of Ia antigens, with the possible exception of acute lymphatic leukemia cells (Ia+, gamma-chain-)."
5.	Inflammation 10/01/1990 - "This study compared the tissue distribution and cellular expression of Ia antigen in jejunal and ileal epithelium at various stages of intestinal inflammation produced by infecting rats with the nematode parasite Nippostrongylus brasiliensis. " 05/25/2007 - "In addition, there were lower levels of expression of major histocompatibility complex (MHC) class II antigens and a smaller number of activated microglia in the ipsilateral SN in intrastriatal rhEPO-treated rats than that in control rats at 2 weeks, suggesting that intrastriatal injection of rhEPO attenuated 6-OHDA-induced inflammation in the ipsilateral SN. " 01/01/2007 - "During inflammation, a majority of resident DCs undergo maturation by acquiring high expression of major histocompatibility complex class II antigens and B7 (CD80/CD86) and CD40 costimulatory molecules. " 03/01/2006 - "Although MHC class II antigen processing via autophagy has so far mainly been described for professional antigen-presenting cells like B cells, macrophages, and dendritic cells, it might be even more important for cells with less endocytic potential, like epithelial cells, when these express MHC class II at sites of inflammation. " 05/01/2005 - "K8-/- mice show early signs of inflammation even prior to weaning, that increases with age, and their epithelial cells overexpress MHC class II antigens. "

Related Drugs and Biologics

1.	Antigens
2.	HLA-DR Antigens (HLA-DR)
3.	HLA-DQ Antigens (HLA-DQ)
4.	DNA (Deoxyribonucleic Acid)
5.	Isoantigens (Alloantigen)
6.	I-antigen
7.	Proteins (Proteins, Gene)
8.	HLA-DP Antigens (HLA-DP)
9.	HLA-DR8
10.	N-Acetylneuraminic Acid (Sialic Acid)

Related Therapies and Procedures

1.	Immunotherapy
2.	Homologous Transplantation (Allograft)
3.	Ligation
4.	Transplants (Transplant)
5.	Transplantation (Transplant Recipients)