[Antioxidants in malignant neoplasms in humans and animals].

Abstract

This review is devoted to the role of low molecular weight antioxidants and antioxidant enzymes in cancerogenesis. The data on accumulation of lipid-soluble and water-soluble antioxidants in a number of malignant human and experimental tumors especially in the renal cell carcinoma tissues are analyzed. A possibility is discussed concerning the pro- and anticarcinogenic effects of the abundant tumor content of antioxidants. Implication of antioxidants in tumor resistance to chemotherapeutic drugs and ionizing radiation is discussed.

• Authors: N V Nikiforova, A E Berman
• Journal: Biomeditsinskaia khimiia (Biomed Khim) 2003 May-Jun Vol. 49 Issue 3 Pg. 250-62 ISSN: 2310-6972 [Print] Russia (Federation)
• Vernacular Title: Antioksidanty v zlokachestvennykh opukholiakh cheloveka i zhivotnogo.
• PMID: 14564734 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Antioxidants

Topics

• Animals
• Antioxidants (chemistry, metabolism)
• Apoptosis
• Humans
• Lipid Peroxidation
• Molecular Weight
• Neoplasms (enzymology, metabolism, pathology)