Abstract | PURPOSE: MATERIALS AND METHODS: RESULTS: Overall 5,510 patients with complete clinical and pathological information were included in the study. Lymph nodes metastases were present in 206 patients (3.7%). Pretreatment PSA, biopsy Gleason sum, clinical stage and institution represented predictors of lymph node status (p <0.001). Bootstrap corrected predictive accuracy of the 3-variable nomogram (clinical stage, Gleason sum and PSA) was 0.76. Inclusion of a fourth variable, which accounts for institutional differences in lymph node metastases, yielded an area under the receiver operating characteristics curve of 0.78. The negative predictive value of our nomograms was 0.99 when they predicted 3% or less chance of positive lymph nodes. CONCLUSIONS: Using clinical information, we produced 2 calibrated and validated nomograms, which accurately predict pathologically negative lymph nodes in men with localized prostate cancer who are candidates for radical prostatectomy.
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Authors | Ilias Cagiannos, Pierre Karakiewicz, James A Eastham, Makato Ohori, Farhang Rabbani, Claudia Gerigk, Victor Reuter, Markus Graefen, Peter G Hammerer, Andreas Erbersdobler, Hartwig Huland, Patrick Kupelian, Eric Klein, David I Quinn, Susan M Henshall, John J Grygiel, Robert L Sutherland, Phillip D Stricker, Christopher G Morash, Peter T Scardino, Michael W Kattan |
Journal | The Journal of urology
(J Urol)
Vol. 170
Issue 5
Pg. 1798-803
(Nov 2003)
ISSN: 0022-5347 [Print] United States |
PMID | 14532779
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Biomarkers, Tumor
- Prostate-Specific Antigen
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
(blood)
- Humans
- Logistic Models
- Lymph Node Excision
- Lymph Nodes
(pathology)
- Lymphatic Metastasis
(pathology)
- Male
- Middle Aged
- Neoadjuvant Therapy
- Neoplasm Staging
- Predictive Value of Tests
- Probability
- Prostate-Specific Antigen
(blood)
- Prostatectomy
- Prostatic Neoplasms
(pathology, surgery)
- Salvage Therapy
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