Impact of selected factors on early graft function in patients after renal transplantation.

Abstract

Transplantation is the best treatment for end-stage renal diseases. For transplantologists, it is most important to know the factors that worsen graft survival prognosis. The aim of the study was to investigate factors predictive of graft loss and shortened graft survival. We retrospectively reviewed 442 renal transplant patients between 1990 and 1995 in two Szczecin units, all of whom received a triple-drug immunosuppressive regimen. One hundred thirty patients showed graft disorders such as delayed graft function or primary nonfunction. The occurrence of these disorders was examined as a function of donor and recipient age and sex, cause of ESRD, HLA compatibility, ABO and Rh compatibility, cold ischemia time, warm ischemia time, antileukocyte antibody level (PRA), and period of dialysis therapy before transplantation. The study showed that a high maximal PRA level, incompatibility for ABO group, and a longer warm ischemia time increase the probability of early graft function disorders.

• Authors: J Sieńko, M Wiśniewska, M Ostrowski, K Ciechanowski, K Safranow, A Chudyk, A Fronczyk, J Rozański, M Kamiński, T Sulikowski, M Romanowski, K Pabisiak, M Paczkowski, A Mizerski
• Journal: Transplantation proceedings (Transplant Proc) Vol. 35 Issue 6 Pg. 2167-9 (Sep 2003) ISSN: 0041-1345 [Print] United States
• PMID: 14529877 (Publication Type: Journal Article)

Chemical References

• ABO Blood-Group System
• Rh-Hr Blood-Group System

Topics

• ABO Blood-Group System
• Age Factors
• Blood Group Incompatibility
• Female
• Graft Survival (immunology, physiology)
• Histocompatibility Testing
• Humans
• Kidney Failure, Chronic (surgery)
• Kidney Transplantation (immunology, physiology)
• Male
• Retrospective Studies
• Rh-Hr Blood-Group System
• Sex Characteristics
• Treatment Outcome