Abstract |
Four patients with intractable hiccup were treated in a double-blind, randomized, placebo, cross-over study with an analogue of gamma-aminobutyric acid, Baclofen. There was a consistent and statistically significant (p = 0.03) improvement in hiccup severity with Baclofen, both subjectively (p = 0.03) and by hiccup-free periods (p = 0.003). The actual frequency of hiccup was not significantly altered by the medication. We propose that the mechanical aspects of hiccup are reduced by Baclofen, leading to a perceptual blockage and a decrease in the reflex severity induced by the gamma-aminobutyric acid analogue. We conclude that this medication may be useful for the treatment of intractable hiccup.
|
Authors | F C Ramírez, D Y Graham |
Journal | The American journal of gastroenterology
(Am J Gastroenterol)
Vol. 87
Issue 12
Pg. 1789-91
(Dec 1992)
ISSN: 0002-9270 [Print] United States |
PMID | 1449142
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
|
Chemical References |
|
Topics |
- Aged
- Baclofen
(therapeutic use)
- Dose-Response Relationship, Drug
- Double-Blind Method
- Hiccup
(drug therapy)
- Humans
- Male
- Middle Aged
- Treatment Outcome
|