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Baclofen

A GAMMA-AMINOBUTYRIC ACID derivative that is a specific agonist of GABA-B RECEPTORS. It is used in the treatment of MUCSCLE SPASTICITY, especially that due to SPINAL CORD INJURIES. Its therapeutic effects result from actions at spinal and supraspinal sites, generally the reduction of excitatory transmission.

Also Known As:

ASTA Medica Brand of Baclofen; Alphapharm Brand of Baclofen; Apo-Baclofen; Apotex Brand of Baclofen; Ashbourne Brand of Baclofen; Athena Brand of Baclofen; Atrofen; Ba-34,647; Ba-34647; Baclofen AWD; Baclofène-Irex; Baclospas; CIBA-34,647-BA; Ciba-Geigy Brand of Baclofen; Clofen; Gen-Baclofen; Genpharm; Irex Brand of Baclofen; Isis Brand of Baclofen; Lebic; Lioresal; Liorésal; Medtronic Brand of Baclofen; Novartis Brand of Baclofen; Nu-Baclo; Nu-Pharm Brand of Baclofen; PCP-GABA; PMS-Baclofen; Pharmascience Brand of Baclofen; beta-(Aminomethyl)-4-chlorobenzenepropanoic Acid; beta-(p-Chlorophenyl)-gamma-aminobutyric Acid; AWD, Baclofen; Apo Baclofen; ApoBaclofen; Ba34,647; Ba34647; Baclofen Alphapharm Brand; Baclofen Apotex Brand; Baclofen Ashbourne Brand; Baclofen Athena Brand; Baclofen Ciba-Geigy Brand; Baclofen Irex Brand; Baclofen Isis Brand; Baclofen Medtronic Brand; Baclofen Novartis Brand; Baclofen Nu-Pharm Brand; Baclofen Pharmascience Brand; Baclofène Irex; BaclofèneIrex; CIBA34,647BA; Ciba Geigy Brand of Baclofen; GABA, Chlorophenyl; Gen Baclofen; GenBaclofen; Nu Baclo; Nu Pharm Brand of Baclofen; NuBaclo; PMS Baclofen; PMSBaclofen; Baclophen; Chlorophenyl GABA; Benzenepropanoic acid, beta-(aminomethyl)-4-chloro-

Networked: 1699 relevant articles (242 outcomes, 227 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Carboxylic Acids: 83
  - Acyclic Acids
    - Butyric Acids: 11
      - Aminobutyric Acids: 449
        gamma-Aminobutyric Acid: 6435
        Baclofen: 1699
        phaclofen: 19
        saclofen: 11
        arbaclofen placarbil: 8
        2-hydroxysaclofen: 6
        gamma-guanidinobaclofen: 1
        2-(4-chlorophenyl)-4-aminobutyric acid
        2-amino-2-(4-chlorophenyl)ethanesulfonic acid
        3-(4-chlorophenyl)-4-hydroxybutyric acid
        5-amino-3-(4-chlophenyl)pentanoic acid
        5-hydroxysaclofen
        CGP 11130

Experts

1.	Leggio, Lorenzo: 11 articles (05/2015 - 09/2003)
2.	Addolorato, Giovanni: 11 articles (04/2013 - 09/2003)
3.	Yablon, Stuart A: 9 articles (02/2015 - 10/2004)
4.	Stokic, Dobrivoje S: 9 articles (02/2015 - 10/2004)
5.	Rolland, Benjamin: 9 articles (01/2015 - 11/2010)
6.	Cottencin, Olivier: 9 articles (01/2015 - 11/2010)
7.	Kofler, Markus: 9 articles (02/2013 - 01/2009)
8.	Deheul, Sylvie: 8 articles (01/2015 - 11/2010)
9.	Bordet, Régis: 8 articles (01/2015 - 11/2010)
10.	Krach, Linda E: 7 articles (05/2014 - 03/2004)

Related Diseases

1.	Pain (Aches) 04/01/2009 - "Baclofen was effective in 21 of 25 patients and significantly reduced Numeric Rating Scale (pain score, 0-10; P < .0001). " 10/01/2006 - "The good clinical response to treatment of spasticity and rigidity, improved quality of life, pain reduction and patient satisfaction with short length of admission demonstrate the efficacy of intrathecal baclofen therapy. " 09/01/2003 - "Baclofen, a presynaptic muscle relaxant is also beneficial in trigeminal pain. " 01/01/2010 - "The present study indicates that the combined treatment of acupuncture and baclofen is more effective than baclofen treatment alone to reduce pain in patients with non-specific chronic LBP. " 04/01/2011 - "Baclofen is effective in attenuating pain associated responses in an experimental model of FD and appears to act by central mechanisms. "
2.	Dystonia (Limb Dystonia) 04/21/2003 - "Continuous intrathecal baclofen was effective in treating severe spasticity and dystonia of cerebral origin with major effect on muscles of the lower extremities, pelvis, and back and in particular opisthotonus was relieved. " 01/01/2015 - "Treatment of severe spasticity and dystonia with intrathecal baclofen (ITB) in children has been shown to be effective and has therefore been employed in the Region of Southern Denmark. " 02/01/1999 - "Chronic intrathecal baclofen therapy via pump has been effective in this case and should be considered as a treatment modality in carefully selected patients with dystonia." 01/01/1992 - "Baclofen can be an effective treatment for childhood dystonia." 01/01/1998 - "Intrathecal baclofen infusion is a promising treatment option for generalized dystonia associated with CP. "
3.	Spasm (Spasms) 08/01/1992 - "Baclofen dramatically reduced spasms, resulting in more stable ventilation, improved ease of care, reduced distress and better integration into the community. " 07/01/2004 - "The Ashworth scale, the Spasms Frequency Scale, and the FIM motor score showed a significant improvement in all patients after the onset of therapy with baclofen. " 09/01/1997 - "In every case intrathecal baclofen therapy resulted in a statistically significant reduction in upper- and lower-extremity tone, spasm frequency, and reflexes, contributing to improved functional abilities. " 05/01/2003 - "This literature review shows evidence that intrathecally administered baclofen is effective in reducing the positive signs of spasticity (tone, spasms, reflex activity). " 01/01/1990 - "Lioresal is effective in reducing spasms. "
4.	Cerebral Palsy (Spastic Diplegia) 09/01/2007 - "Intrathecal baclofen (ITB) therapy can be very effective in the treatment of intractable spasticity, but its effectiveness and safety have not yet been thoroughly studied in children with cerebral palsy (CP). " 05/01/2009 - "The results of this randomised controlled trial establish continuous infusion of intrathecal baclofen to be effective in carefully selected children with problems caused by intractable spastic cerebral palsy." 01/01/2015 - "To determine whether intrathecal baclofen is an effective treatment for spasticity in children with cerebral palsy. " 02/01/2010 - "Intrathecal baclofen is an effective treatment for spasticity in patients with cerebral palsy. " 09/01/2008 - "Intrathecal baclofen (ITB) is an effective treatment of spasticity in patients with cerebral palsy. "
5.	Spinal Cord Injuries (Spinal Cord Injury) 10/01/1987 - "Oral baclofen may be effective in patients with spasticity due to spinal cord injury or disease." 08/01/2002 - "This study demonstrates that chronic intrathecal baclofen infusion is a safe and effective form of treatment of intractable spasticity in patients with spinal cord injury. " 06/01/1993 - "Thus far, intrathecal baclofen administration shows promise in the treatment of spasticity resulting from spinal cord trauma. " 06/01/1993 - "Studies were selected for review if they evaluated intrathecal baclofen in patients with spinal cord injury. " 06/01/2015 - "Baclofen or nNOS inhibitor affect molecular and behavioral alterations evoked by traumatic spinal cord injury in rat spinal cord."

Related Drugs and Biologics

1.	gamma-Aminobutyric Acid (GABA)
2.	GABA-B Receptor Agonists
3.	GABA Agonists (GABA Receptor Agonists)
4.	gabapentin (Neurontin)
5.	Carbamazepine (Tegretol)
6.	tizanidine (Zanaflex)
7.	Morphine (MS Contin)
8.	Clonidine (ST 155)
9.	Diazepam (Valium)
10.	Carbon Monoxide

Related Therapies and Procedures

1.	Injections
2.	Oral Administration
3.	Transcutaneous Electric Nerve Stimulation (TENS)
4.	Drug Therapy (Chemotherapy)
5.	Analgesia