EM 405: a new compound with analgesic and anti-inflammatory properties and no gastrointestinal side-effects.

Abstract

EM 405 has analgesic and antitussive effects, probably exerted by noradrenaline uptake inhibition and local anaesthetic actions. It showed anti-inflammatory, which may be due to anti-histaminic and indirect sympathomimetic properties. As oral application of EM 405 did not induce gastrointestinal side effects a possible ulcer preventing action was investigated. EM 405 reduced gastric ulcers induced by ethnology or indomethacin with ED50 values of 45 and 26 mg/kg p.o. Stress-induced ulcer was inhibited with an ED50 of 34 mg/kg. EM 405 reduced basal and stimulated gastric secretion by reducing volume as well as H(+)- and Cl(-)-production. Therefore ulcer prevention by EM 405 may be explained by its inhibitory effects on gastric secretion. The results characterise EM 405 as a novel anti-inflammatory compound with ulcer-protective action.

• Authors: N Selve, E Friderichs, I Graudums
• Journal: Agents and actions (Agents Actions) Vol. Spec No Pg. C84-5 ( 1992) ISSN: 0065-4299 [Print] Switzerland
• PMID: 1442341 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Cyclohexanes
• Cyclohexenes
• EM 405
• Pentagastrin

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (pharmacology, toxicity)
• Cyclohexanes (administration & dosage, pharmacology, toxicity)
• Cyclohexenes
• Gastric Acid (metabolism)
• Male
• Pentagastrin (pharmacology)
• Rats
• Rats, Sprague-Dawley
• Stomach Ulcer (chemically induced, drug therapy, prevention & control)
• Stress, Physiological