A murine CD4-, CD8- T cell receptor-gamma delta T lymphocyte clone specific for herpes simplex virus glycoprotein I.

Abstract

The role of TCR-gamma delta T lymphocytes in immune responses is currently not well understood. TCR-gamma delta cells have a limited repertoire suggesting that TCR-gamma delta T a limited number of evolutionarily conserved Ag such as nonpolymorphic MHC and heat shock proteins. TCR-gamma delta T lymphocytes appear in enhanced numbers in skin lesions produced by Mycobacterium leprae and in the synovial fluid of joints affected by rheumatoid arthritis, raising the possibility that this subset of T lymphocytes may play a role in control of infectious processes and in autoimmune diseases. We report the identification of a TCR-gamma delta T cell clone isolated from a HSV-infected mouse that recognizes glycoprotein I of HSV type 1. Clone recognition of glycoprotein I does not appear to require the expression of MHC class I or class II gene products. These data suggest that TCR-gamma delta lymphocytes may play an important role in the immune response to viral infections.

• Authors: R M Johnson, D W Lancki, A I Sperling, R F Dick, P G Spear, F W Fitch, J A Bluestone
• Journal: Journal of immunology (Baltimore, Md. : 1950) (J Immunol) Vol. 148 Issue 4 Pg. 983-8 (Feb 15 1992) ISSN: 0022-1767 [Print] United States
• PMID: 1310711 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• CD4 Antigens
• CD8 Antigens
• Glycoproteins
• Receptors, Antigen, T-Cell, gamma-delta
• Viral Envelope Proteins

Topics

• Animals
• CD4 Antigens (analysis)
• CD8 Antigens (analysis)
• Clone Cells
• Glycoproteins (immunology)
• Herpes Simplex (immunology)
• Mice
• Mice, Inbred Strains
• Receptors, Antigen, T-Cell, gamma-delta (analysis)
• Simplexvirus (immunology)
• T-Lymphocytes (immunology, physiology)
• Viral Envelope Proteins (immunology)