Abstract | UNLABELLED: The binding of autoimmune anticardiolipin antibodies to phospholipid has been shown to require a plasma cofactor, beta-2-glycoprotein 1 (beta2-GPI). Antibodies against beta2-GPI are associated with both venous and arterial thrombosis in adults and have been suggested as a new antiphospholipid syndrome marker. We present six children with cerebral thrombosis at the age of 0-12 months, who had IgG antibodies to beta2-GPI (titers 26, 29, 31, 39, 101 and 109 SGU, when 20 SGU was the cut-off). In at least four patients, the conventional antiphospholipid markers ( lupus anticoagulant and IgG and IgM anticardiolipin) were negative. All six children had normal results in the other routine thrombophilia assays (thrombin time, antithrombin, protein C, protein S, factor V Leiden mutation, prothrombin mutation). CONCLUSION:
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Authors | Freja Ebeling, Jari Petäjä, Soile Alanko, Aune Hirvasniemi, Tarja Holm, Marja Lähde, Auli Nuutila, Helena Pesonen, Elina Vahtera, Vesa Rasi |
Journal | European journal of pediatrics
(Eur J Pediatr)
Vol. 162
Issue 10
Pg. 678-81
(Oct 2003)
ISSN: 0340-6199 [Print] Germany |
PMID | 12915983
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Anticardiolipin
- Glycoproteins
- Membrane Glycoproteins
- beta 2-Glycoprotein I
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Topics |
- Antibodies, Anticardiolipin
(immunology)
- Female
- Glycoproteins
(immunology)
- Humans
- Infant
- Intracranial Thrombosis
(immunology)
- Male
- Membrane Glycoproteins
(immunology)
- Stroke
(immunology)
- beta 2-Glycoprotein I
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