Abstract | PURPOSE OF REVIEW: RECENT FINDINGS:
Myeloperoxidase generates reactive oxidant species as part of its function in innate host defense mechanisms. The reactive species formed, however, may also damage normal tissues, contributing to inflammatory injury. Recent studies suggest that MPO-generated oxidants participate in multiple processes relevant to cardiovascular disease development and outcomes, including induction of foam cell formation, endothelial dysfunction, development of vulnerable plaque, and ventricular remodeling following acute myocardial infarction. Of note, measurements of myeloperoxidase mass and activity may be useful in cardiac risk stratification, both for chronic disease assessment, as well as in identification of patients at risk in the acute setting. SUMMARY:
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Authors | Marie-Luise Brennan, Stanley L Hazen |
Journal | Current opinion in lipidology
(Curr Opin Lipidol)
Vol. 14
Issue 4
Pg. 353-9
(Aug 2003)
ISSN: 0957-9672 [Print] England |
PMID | 12865732
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S., Review)
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Chemical References |
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Topics |
- Animals
- Biomarkers
(analysis)
- Cardiovascular Diseases
(enzymology, pathology)
- Clinical Trials as Topic
- Humans
- Lipid Peroxidation
- Oxidative Stress
(physiology)
- Peroxidase
(metabolism)
- Risk Assessment
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