Regulation of bone resorption and formation by purines and pyrimidines.

Abstract

Growing evidence suggests that extracellular nucleotides, signalling through P2 receptors, might play important roles in the regulation of bone and cartilage metabolism. ATP and other nucleotides can exert impressive stimulatory effects on the formation and activity of osteoclasts (bone-resorbing cells) in addition to inhibiting bone formation by osteoblasts. In this review, the current understanding of the actions of nucleotides on skeletal cells and the probable receptor subtypes involved are discussed.

• Authors: Astrid Hoebertz, Timothy R Arnett, Geoffrey Burnstock
• Journal: Trends in pharmacological sciences (Trends Pharmacol Sci) Vol. 24 Issue 6 Pg. 290-7 (Jun 2003) ISSN: 0165-6147 [Print] England
• PMID: 12823955 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Purine Nucleotides
• Pyrimidine Nucleotides
• Receptors, Purinergic P2

Topics

• Bone Resorption (metabolism)
• Bone and Bones (cytology, metabolism)
• Humans
• Osteogenesis (physiology)
• Purine Nucleotides (metabolism)
• Pyrimidine Nucleotides (metabolism)
• Receptors, Purinergic P2 (metabolism)