Abstract |
This commentary reviews the data on HLA-A2-restricted CD8 T cells specific for peptide (540-548) derived from hTERT (human telomerase reverse transcriptase). Several studies have reported the successful generation of such T cells (1, 2, 3). However, tumor recognition was observed in some, but not all, studies. More data are required to elucidate whether hTERT peptide (540-548) -specific T cells can indeed recognize and destroy tumor cells. It would be highly useful if telomerase would emerge as a universal tumor antigen that can be targeted in the cancer immunotherapy of HLA-A2 positive patients.
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Authors | Daniel E Speiser, Jean-Charles Cerottini, Pedro Romero |
Journal | Cancer immunity
(Cancer Immun)
Vol. 2
Pg. 14
(Oct 14 2002)
ISSN: 1424-9634 [Electronic] United States |
PMID | 12747759
(Publication Type: Journal Article, Review)
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Chemical References |
- Peptide Fragments
- telomerase reverse transcriptase (540-548)
- Telomerase
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Topics |
- CD8-Positive T-Lymphocytes
(cytology, immunology)
- Cytotoxicity, Immunologic
- Humans
- Neoplasms
(enzymology, immunology, pathology)
- Peptide Fragments
(immunology)
- T-Lymphocytes, Cytotoxic
(cytology, immunology)
- Telomerase
(immunology)
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