Prognostic significance of UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-3 (GalNAc-T3) expression in patients with gastric carcinoma.

Abstract	Aberrant glycosylation occurs during development of gastric carcinomas. The initiation of mucin-type O-glycosylation is regulated by GalNAc-T3 (UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase-3). However, the clinical significance of GalNAc-T3 expression in human gastric carcinoma has not yet been demonstrated. In the present study, we investigated the relationship between immunohistochemical GalNAc-T3 expression and various clinicopathologic factors, including prognosis, in 117 gastric carcinoma patients. Of 117 gastric carcinomas examined, 59 (50.4%) showed strong expression of GalNAc-T3. Strong expression was detected in 38 of 59 (64.4%) differentiated type and in 21 of 58 (36.2%) undifferentiated gastric carcinomas, indicating that the expression of GalNAc-T3 correlated significantly with tumor differentiation (P=0.0023, chi2 test). Overall 5-year survival rate in patients with strong GalNAc-T3 expression (71.0%) was significantly better than that of patients with weak expression (49.3%) (P=0.0197, log-rank test). Multivariate analysis identified GalNAc-T3 expression as an independent prognostic factor (P=0.0158, Cox proportional hazards model). Our data suggest that GalNAc-T3 expression may be a useful marker for prognosis and differentiation of gastric carcinomas.
Authors	Koji Onitsuka, Kazunori Shibao, Yoshifumi Nakayama, Noritaka Minagawa, Keiji Hirata, Hiroto Izumi, Ken-ichi Matsuo, Naoki Nagata, Kenji Kitazato, Kimitoshi Kohno, Hideaki Itoh
Journal	Cancer science (Cancer Sci) Vol. 94 Issue 1 Pg. 32-6 (Jan 2003) ISSN: 1347-9032 [Print] England
PMID	12708471 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Biomarkers, Tumor Neoplasm Proteins N-Acetylgalactosaminyltransferases polypeptide N-acetylgalactosaminyltransferase
Topics	Adult Aged Aged, 80 and over Biomarkers, Tumor (analysis) Carcinoma (enzymology, mortality, pathology) Cell Differentiation Female Humans Immunoenzyme Techniques Japan (epidemiology) Male Middle Aged N-Acetylgalactosaminyltransferases (analysis) Neoplasm Proteins (analysis) Prognosis Stomach Neoplasms (enzymology, mortality, pathology) Survival Analysis

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