Comparative clinical and microbiological effects of subgingival metronidazole application in adult periodontitis; 12-months results.

Abstract	The aim of the present study was to evaluate the clinical and microbiological effects of subgingival application of 25% metronidazole dental gel as an adjunct to scaling and root planing (SRP) in the treatment of adult periodontitis. Eighty teeth in 18 patients were evaluated using a split mouth design. The test teeth received SRP and a 25% metronidazole gel applied subgingivally on days 0 and 7. The control teeth received SRP only. Clinical and microbiological examinations were carried out before treatment and on weeks 1, 3, 7, 13, 26, 38 and 52 of the experimental period. Colony forming units of Porphyromonas gingivalis and Prevotella intermedia / Prevotella nigrescens were determined. Both treatments provided significant improvements in all the clinical and microbiological parameters (P<0.05). However, none of the differences between the study groups were statistically significant (P > 0.05). As a conclusion, the present study does not provide evidence in favour of the routine use of adjunctive metronidazole dental gel in the treatment of adult periodontitis.
Authors	E Buduneli, A Tünger, E Evrenosoglu, A Bilgiç
Journal	Journal of the International Academy of Periodontology (J Int Acad Periodontol) Vol. 3 Issue 4 Pg. 81-6 (Oct 2001) ISSN: 1466-2094 [Print] England
PMID	12666946 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References	Anti-Bacterial Agents Gels Metronidazole
Topics	Administration, Topical Adult Analysis of Variance Anti-Bacterial Agents (administration & dosage, therapeutic use) Colony Count, Microbial Combined Modality Therapy Dental Scaling Female Follow-Up Studies Gels Gingival Hemorrhage (drug therapy, microbiology) Humans Male Metronidazole (administration & dosage, therapeutic use) Middle Aged Periodontal Attachment Loss (drug therapy, microbiology) Periodontal Pocket (drug therapy, microbiology) Periodontitis (drug therapy, microbiology) Porphyromonas gingivalis (drug effects) Prevotella (drug effects) Prevotella intermedia (drug effects) Root Planing Single-Blind Method Statistics as Topic

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!