[A quantitatively pathological study on malignant ameloblastomas].

Abstract

OBJECTIVE:

The purpose of this study was to investigate the role of nuclear morphometric parameters, DNA content and Ag-NOR count in the differentiating malignant and benign ameloblastomas.

METHODS:

Totally 17 cases of malignant ameloblastomas were examined by using HE, AgNOR and DNA stain methods. Morphometric parameters of cell nuclei, DNA content and AgNOR count were quantitatively studied by using an image analysis system.

RESULTS:

Seven parameters (area, perimeter, equal diameter, minor diameter, mean diameter, round index, axis ratio) out of ten shape factors were significantly different between malignant and benign ameloblastoma (P < 0.01). AgNOR count and DNA index in malignant ameloblastoma were significantly higher than those in benign ameloblastoma (P < 0.01). Logistic regression equation was established, according to nuclear morphormetric parameters and DNA index.

CONCLUSION:

Quantitative analysis of DAN content, nuclear morphmetric parameters and AgNOR count may be helpful in differentiating malignant and benign ameloblastomas.

• Authors: Jinzhong Liu, Shuozhi Wang, Xinming Chen
• Journal: Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology (Hua Xi Kou Qiang Yi Xue Za Zhi) Vol. 20 Issue 3 Pg. 187-9 (Jun 2002) ISSN: 1000-1182 [Print] China
• PMID: 12600062 (Publication Type: English Abstract, Journal Article)

Chemical References

• DNA, Neoplasm

Topics

• Adolescent
• Adult
• Aged
• Ameloblastoma (pathology)
• Child
• DNA, Neoplasm (analysis)
• Female
• Humans
• Image Processing, Computer-Assisted
• Male
• Middle Aged
• Nucleolus Organizer Region (ultrastructure)
• Odontogenic Tumors (pathology)
• Silver Staining