Ameloblastoma

An immature epithelial tumor of the JAW originating from the epithelial rests of Malassez or from other epithelial remnants of the ENAMEL from the developmental period. It is a slowly growing tumor, usually benign, but displays a marked propensity for invasive growth.

Also Known As:

Networked: 1169 relevant articles (16 outcomes, 268 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Dentigerous Cyst
2.	Neoplasms (Cancer)
3.	Odontogenic Cysts (Keratocyst)
4.	Squamous Cell Carcinoma (Epidermoid Carcinoma)
5.	Odontogenic Tumors (Dental Tissue Neoplasm)

Experts

1.	Zhong, Ming: 32 articles (04/2022 - 07/2002)
2.	Bologna-Molina, Ronell: 20 articles (05/2024 - 04/2009)
3.	Kumamoto, Hiroyuki: 19 articles (09/2014 - 01/2002)
4.	Siar, Chong Huat: 17 articles (08/2019 - 09/2002)
5.	Wang, Jie: 16 articles (07/2017 - 07/2002)
6.	Ooya, Kiyoshi: 15 articles (09/2007 - 01/2002)
7.	Gomez, Ricardo Santiago: 14 articles (05/2024 - 01/2010)
8.	Nagatsuka, Hitoshi: 13 articles (01/2017 - 09/2002)
9.	Kumamoto, H: 12 articles (09/2008 - 04/2001)
10.	Ooya, K: 12 articles (09/2008 - 04/2001)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ameloblastoma:

1.	Mitogen-Activated Protein KinasesIBA 08/01/2021 - "Recent studies have identified recurrent somatic and activating mutations in the mitogen-activated protein kinase (MAPK) and sonic hedgehog (SHH) signalling pathways in ameloblastoma. " 04/28/2023 - "Ameloblastoma in 66% of the cases harbor a somatic mutation of the "mitogen-activated protein kinase" signaling pathway (BRAF V600E). " 04/01/2023 - "The molecular pathogenesis of ameloblastoma is attributed to aberrant activity of the signal transduction pathways relating to developmental stages of odontogenesis including the mitogen-activated protein kinase (MAPK) pathway. " 01/01/2022 - "Recent reports have revealed that ameloblastoma harbours an oncogenic BRAFV600E mutation with mitogen-activated protein kinase (MAPK) pathway activation and described cases of ameloblastoma harbouring a BRAFV600E mutation in which patients were successfully treated with a BRAF inhibitor. " 11/01/2014 - "We sought to characterize pathogenic mutations in ameloblastoma and their clinical and functional significance with an emphasis on the mitogen-activated protein kinase (MAPK) pathway. "
2.	Proteins (Proteins, Gene)FDA Link 07/01/2023 - "A proteomics study to explore differential proteins associated with the pathogenesis of ameloblastoma." 09/01/2022 - "The objective of this study consisted in analyzing the expression of this protein in ameloblastoma and tooth germ. " 07/01/2020 - "This study aimed to evaluate BRAF V600E gene mutation and expression of its related proteins with clinicopathologic parameters in conventional ameloblastoma. " 07/01/2020 - "The aim of this study was to investigate whether PTEN promoter methylation contributes to PTEN inactivation in ameloblastoma and its associated protein expression. " 01/01/2018 - "The aim of this study was to investigate alterations in the EGFR gene and its protein expression for a better understanding of the biologic behavior of ameloblastoma. "
3.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/01/2006 - "In the present study, from the flow cytometry results, we found that the prolonged-treatment of TNFalpha until 24 h, resulted apoptosis in AM-1 cells (ameloblastoma cell line). " 07/01/2005 - "In the present study, we found that RANKL and TNFalpha were expressed and secreted by ameloblastoma cells, and was proven to induce osteoclastogenesis. " 01/01/2006 - "Inhibition of Akt and MAPK pathways elevated potential of TNFalpha in inducing apoptosis in ameloblastoma." 07/01/2005 - "These results suggested that ameloblastoma by secreting RANKL and TNFalpha could induce osteoclastogenesis." 05/01/2005 - "Expression of TNFalpha, TRAIL, and their receptors in tooth germs and ameloblastomas suggests that these death factors might be involved in cytodifferentiation of odontogenic epithelium and tissue structuring of ameloblastomas. "
4.	AntibodiesIBA 04/01/1985 - "Collectively, these studies indicate that the use of specific antibodies to basement membrane components may help to differentiate ameloblastomas from malignant lesions." 01/01/2021 - "Here, we performed BRAF V600E mutation analysis, examined the expression pattern of VE1 IHC, and comparatively evaluated the performance of two VE1 antibodies in ameloblastomas, OCs and BMOTs. " 09/01/2014 - "Tissue specimens of nine dental follicles and 69 ameloblastomas were immunohistochemically examined with antibodies against ATG7, LC3, and p62. " 03/01/2006 - "Tissue specimens of 10 tooth germs, 40 benign ameloblastomas, and five malignant ameloblastomas were examined immunohistochemically with the use of antibodies against RB, E2F-1, and phosphorylated RB. " 02/01/2003 - "Frozen tissue sections of seven tooth germs and 22 ameloblastomas were immunohistochemically examined using anti-MMP-1, -2 and -9 and anti-TIMP-1 and -2 antibodies. "
5.	Biomarkers (Surrogate Marker)IBA 05/01/2023 - "Identification of key biomarkers related to epithelial-mesenchymal transition and immune infiltration in ameloblastoma using integrated bioinformatics analysis." 01/01/2022 - "Potential Biomarkers and Signaling Pathways Associated with the Pathogenesis of Primary Ameloblastoma: A Systems Biology Approach." 11/01/2016 - "Immunohistochemical biomarkers in ameloblastomas." 01/01/2018 - "Does volumetric measurement serve as an imaging biomarker for tumor aggressiveness of ameloblastomas?" 06/01/2013 - "With advances in the elucidation of molecular signaling mechanisms in cells, the cytodifferentiation of epithelial tumor cells in ameloblastomas and AOTs can be identified using different biomarkers. "
6.	Dental Implants (Dental Implant)IBA 01/01/2018 - "Oral and masticatory rehabilitation using osseointegrated dental implants after resective treatment of multicystic ameloblastoma in the lower jaw with a fibula graft." 02/01/2015 - "Report of multidisciplinary treatment of an extensive mandibular ameloblastoma with free iliac crest bone flap, dental implants, and acellular dermal matrix graft." 12/01/2013 - "This case report includes 1 subject, a patient who presented with a large ameloblastoma treated by resection, a microvascular iliac graft, and dental implants. " 12/01/2013 - "Rehabilitation with dental implants in microvascular iliac graft after solid ameloblastoma resection: a case report." 02/01/2011 - "The aim of this case report is to evaluate the peri-implant clinical status and stability of dental implants placed in patients with advanced-stage mandibular ameloblastomas. "
7.	dabrafenibIBA 07/01/2016 - "A neoadjuvant treatment regime of dabrafenib was given to a patient with recurrent BRAF-mutant mandibular ameloblastoma. " 03/29/2024 - "A recent neoadjuvant therapy targeting BRAF, involving the use of dabrafenib and trametinib, has showcased a promising, safe, and effective strategy for organ preservation in the treatment of mandibular ameloblastoma. " 12/01/2023 - "Neoadjuvant therapy with Dabrafenib and Trametinib was given to a 42-year-old male patient with recurrent ameloblastoma of the right mandible with a BRAF V600E mutation for 18 months. " 10/01/2023 - "BRAF, particularly in the case of metastatic ameloblastoma, inhibitors such as vemurafenib, dabrafenib, and sorafenib, has demonstrated outstanding results. " 10/01/2023 - "BRAF inhibitors like vemurafenib, dabrafenib, and sorafenib have shown excellent results, especially in metastatic ameloblastoma. "
8.	trametinibIBA 03/29/2024 - "A recent neoadjuvant therapy targeting BRAF, involving the use of dabrafenib and trametinib, has showcased a promising, safe, and effective strategy for organ preservation in the treatment of mandibular ameloblastoma. " 12/01/2023 - "Neoadjuvant therapy with Dabrafenib and Trametinib was given to a 42-year-old male patient with recurrent ameloblastoma of the right mandible with a BRAF V600E mutation for 18 months. " 04/28/2023 - "We conducted a literature search, with the search terms "Vemurafenib, Dabrafenib, Ameloblastoma, and BRAF." These included seven case reports with nine patients who underwent monotherapy with Dabrafenib or Vemurafenib or combination therapy with Dabrafenib and Trametinib. " 10/01/2016 - "One patient treated with RT alone for an unresectable ameloblastoma developed a local recurrence and metastases in both the cervical lymph nodes and lungs, but had excellent response to dual BRAF/MEK inhibition with dabrafenib and trametinib. "
9.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 01/01/2017 - "Investigation of cyclooxygenase (COX)-2 in dentigerous cyst and ameloblastoma may help to improve understanding of the nature and behavior of odontogenic cysts and tumors, and in addition may eventually represent a definitive target for a pharmacological approach in the management of these lesions. "
10.	ParaffinIBA 10/01/2022 - "Each ameloblastoma sample was sectioned into two fragments: one was paraffin-embedded while the other one, likewise the dental follicle samples, was fixed in RNAlater and frozen at -196°C. " 09/01/2021 - "Immunohistochemical analysis for CD 99 was performed on paraffin-embedded tissue sections on 50 histopathologically confirmed cases of OKC and ameloblastoma (25 each) arising within the oral cavity and were scored qualitatively, topographically, and according to cellular localization. " 05/01/2021 - "IHC is a reliable test for identifying the BRAF V600E mutation in ameloblastomas, presenting advantages such as being more frequently used in surgical pathology laboratories and requiring fewer critical steps for paraffin-embedded tissue compared with molecular biology techniques." 07/01/2020 - "A subset of 10 paraffin-embedded ameloblastoma samples was examined for PTEN expression through immunohistochemistry. " 01/01/2020 - "In this cross-sectional study, paraffin blocks including 20 cases of ameloblastoma and 20 (AOT), were selected. "

Therapies and Procedures

1.	Curettage 04/25/2024 - "The purpose of this multicentre study was to evaluate the efficacy of the 'dredging-marsupialization-curettage' (D-M-C) strategy in the treatment of conventional intraosseous ameloblastoma of the mandible. " 12/01/2003 - "Primary treatment comprised enucleation and bone curettage in 10 cases and radical surgery in 7. Forty percent of the unicystic lesions and 53.3% of the non-unicystic ameloblastomas of our study presented at least 1 recurrence. " 03/22/2024 - "We report two patients with ameloblastoma under 10 years old who are treated with curettage and fenestration, which is a beneficial method for children with ameloblastoma. " 11/20/2023 - "Curettage combined with bone cavity opening reduces recurrence of the mandibular conventional ameloblastoma and effectively preserves the mandible: a retrospective study." 12/01/2021 - "The most frequently performed treatment option was enucleation plus curettage/peripheral ostectomy in 94 ameloblastomas, followed by segmental resection (60 patients), simple enucleation (46 patients), and marginal resection (40 patients). "
2.	Conservative Treatment 05/01/2020 - "Conservative management is effective in unicystic ameloblastoma occurring from the neonatal period: A case report and a literature review." 11/20/2023 - "In this study, it was found that the recurrence rate of the modified conservative treatment (Cur/BCO) was lower than that of the traditional conservative treatment for managing mandibular conventional ameloblastoma. " 03/01/2021 - "The complication rates, esthetic and functional deficiency were significantly higher in radically treated patients (p<0.05) Conclusions: Our study confirms that higher recurrence rate is associated with conservative treatment for ameloblastoma, while radical treatment leads to an increased number of postoperative complications that affect the patient's quality of life." 01/01/2021 - "Fourteen studies included patients with ameloblastoma who received conservative treatment, and 16 studies reported the overall recurrence rate for patients undergoing aggressive treatment. " 10/01/2019 - "The aim of the present study was to assess the outcomes of radical and conservative treatment approaches of solid/multicystic and unicystic ameloblastoma in terms of recurrence rates. "
3.	Therapeutics 01/01/2024 - "Its association with BRAFV600E mutation is an indication for BRAFV00E-inhibitor therapy The study objective was to identify a sensitive low-cost test for BRAFV600E-positive ameloblastoma. " 11/01/2022 - "New Ameloblastoma Cell Lines Enable Preclinical Study of Targeted Therapies." 04/14/2024 - "The prevalence of the BRAF V600E immunoexpresion may suggest the feasibility of utilizing BRAF-targeted therapy for ameloblastomas with this mutation." 04/05/2024 - "Correction to: Neoadjuvant BRAF-targeted therapy for ameloblastoma of the mandible: an organ preservation approach." 04/05/2024 - "Neoadjuvant BRAF-targeted therapy for ameloblastoma of the mandible: an organ preservation approach."
4.	Mandibular Osteotomy 12/13/2021 - "This study has analyzed 41 patients with mandibular ameloblastoma who underwent a partial mandibulectomy and reconstruction by folding the free fibular flap. " 01/17/2024 - "Two cases were presented who both underwent segmental mandibulectomy for ameloblastoma. " 01/01/2024 - "Symphyseal-Sparing Mandibulectomy for Canine Acanthomatous Ameloblastoma in Dogs: 35 Cases." 06/02/2020 - "A woman of 20-year-old was diagnosed with ameloblastoma, and underwent marginal mandibulectomy when she was 8 years of age. " 06/02/2020 - "In this case report, we describe the successful interdisciplinary orthodontic treatment of a patient with ameloblastoma who underwent marginal mandibulectomy. "
5.	Free Tissue Flaps 01/01/2024 - "Giant ameloblastoma involving the mandibular condyle can be successfully treated with the fibula free flap utilizing mandible reconstruction plates and VSP. " 10/01/2022 - " this study, the authors present their experience in the surgical treatment of mandibular ameloblastomas with vascularized free flap reconstructions. " 04/01/2024 - "Immediate microvascular free flap reconstruction of maxillary and mandibular defects from resection of ameloblastoma is safe and predictable." 12/20/2023 - "Ameloblastoma, Fibula-free flap, Maxillofacial reconstruction, Radical treatment. " 12/20/2023 - "Radical resection of mandibular ameloblastoma and functional reconstruction with a fibula free flap. "