Expression of mRNA of chemokine receptor CXCR4 in feline mammary adenocarcinoma.

Abstract

The expression of mRNA of the chemokine receptor CXCR4 in 65 surgically resected mammary adenocarcinomas from cats was investigated by in situ hybridisation. No expression of the receptor's mRNA was detectable in the mammary tissue of healthy cats, but it was expressed in areas adjacent to necrosis, surrounding blood vessels and cells infiltrating the lymphatics of 47 (72.3 per cent) of the 65 samples. There was a significant relationship between lymphatic infiltration by neoplastic cells and the expression of the receptor's mRNA (P < 0.005), but there was no significant relationship between its expression and the one-year survival of the cats.

• Authors: S Tanabe, T Nakadai, H Furuoka, T Oomachi, Y Kobayashi, Y Omata, T Koyama, E Hondo, Y Uzuka, T Sarashina, R J T Ducusin, T Shida, M E Dorf
• Journal: The Veterinary record (Vet Rec) Vol. 151 Issue 24 Pg. 729-33 (Dec 14 2002) ISSN: 0042-4900 [Print] England
• PMID: 12509077 (Publication Type: Journal Article)

Chemical References

• RNA, Messenger
• Receptors, CXCR4

Topics

• Adenocarcinoma (metabolism, pathology, veterinary)
• Animals
• Base Sequence
• Carcinoma, Ductal, Breast (metabolism, pathology, veterinary)
• Cat Diseases (metabolism, pathology)
• Cats
• Female
• In Situ Hybridization (veterinary)
• Mammary Neoplasms, Animal (metabolism, pathology)
• Molecular Sequence Data
• RNA, Messenger (analysis)
• Receptors, CXCR4 (biosynthesis, genetics)
• Reverse Transcriptase Polymerase Chain Reaction (veterinary)
• Survival Analysis