Analysis of two common alpha 1-antitrypsin deficiency alleles (PI*Z and PI*S) in subjects with periodontitis.

Abstract

BACKGROUND:

pi alpha 1-Antitrypsin deficiency is a genetically determined condition resulting in predisposition to certain inflammatory diseases due to a protease: antiprotease imbalance that is exacerbated by tobacco smoking. Limited evidence suggests that there may be a significant enrichment of mild alpha 1-antitrypsin deficiency phenotypes in subjects with chronic inflammatory periodontal disease.

OBJECTIVE:

To examine the prevalence of two common alpha1-antitrypsin deficiency alleles (PI*Z and PI*S) in a UK population of subjects with periodontitis.

SUBJECTS AND METHODS:

The prevalence of PI*M, PI*S and PI*Z allele combinations was determined in 31 subjects with periodontitis and compared with 31 healthy control subjects matched for smoking status, ethnicity, age and gender. alpha 1-Antitrypsin genotyping was performed by multiplex real-time fluorescence polymerase chain reaction (PCR) using DNA extracted from whole blood.

RESULTS:

There was no difference in the proportion of any alpha 1-antitrypsin genotype found in the diseased and control populations.

CONCLUSIONS:

We did not find evidence to support an association between mutant PI* alleles and periodontitis in a small, controlled study. Larger studies will be required to clarify the relationship between alpha1-antitrypsin genotype and susceptibility to inflammatory periodontal disease.

• Authors: D A Scott, N von Ahsen, R M Palmer, R F Wilson
• Journal: Journal of clinical periodontology (J Clin Periodontol) Vol. 29 Issue 12 Pg. 1118-21 (Dec 2002) ISSN: 0303-6979 [Print] United States
• PMID: 12492914 (Publication Type: Journal Article)

Chemical References

• Trypsin Inhibitors
• alpha 1-Antitrypsin

Topics

• Adult
• Alleles
• Female
• Gene Frequency
• Genotype
• Humans
• Male
• Periodontitis (genetics)
• Polymerase Chain Reaction
• Smoking
• Trypsin Inhibitors (genetics)
• United Kingdom
• alpha 1-Antitrypsin (genetics)
• alpha 1-Antitrypsin Deficiency (genetics)