Abstract | GOALS: We previously showed that endoscopic injection sclerotherapy (EIS) prolonged survival in patients with esophageal varices complicated by hepatocellular carcinoma (HCC) and liver cirrhosis. Here, we evaluated risk factors that affect EIS outcomes. Among factors, the difference between prophylactic and emergency EIS was of interest, and we analyzed precisely. STUDY: RESULTS: During 2-year observation, 22 of the 38 (57.9%) and 38 of the 96 (39.6%) died. Analysis by univariate Cox's proportional hazard model indicated that prognosis of patients receiving emergency EIS was inferior to those with prophylactic EIS. However, multivariate Cox's analysis showed that emergency EIS itself extended survivals of those with esophageal varices complicated by HCC and liver cirrhosis. Patients' hepatic function (Child-Pugh classes) and tumor sizes were also statistically significant factors for survival. Neither prophylactic nor emergency EIS prolonged survival of patients with Child C hepatic function or those with HCCs larger than 5 cm. CONCLUSIONS:
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Authors | Keiji Matsunaga, Ryuichi Iwakiri, Megumi Hara, Hiroyukui Sakata, Tomofumi Ogusu, Ryo Shimoda, Kayoko Oda, Hiroyoshi Utsumi, Kyosuke Yamamoto, Kazuma Fujimoto |
Journal | Journal of clinical gastroenterology
(J Clin Gastroenterol)
Vol. 36
Issue 1
Pg. 68-71
(Jan 2003)
ISSN: 0192-0790 [Print] United States |
PMID | 12488712
(Publication Type: Journal Article)
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Chemical References |
- Oleic Acids
- Sclerosing Solutions
- ethanolamine oleate
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Topics |
- Esophageal and Gastric Varices
(complications, mortality, therapy)
- Humans
- Injections
- Liver Cirrhosis
(complications, mortality)
- Liver Neoplasms
(complications, mortality)
- Oleic Acids
(administration & dosage)
- Prognosis
- Proportional Hazards Models
- Sclerosing Solutions
(administration & dosage)
- Sclerotherapy
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