OBJECTIVE: To investigate the protective and
jaundice-relieving effects of gentiopicrooside (GPS)
injections in mouse and rat models of chemical-induced and immune-mediated hepatic injury. METHODS: Mouse models of chemical-induced liver injury were established by CCl4
injections into the abdominal cavity, mouse models of immune-mediated liver damage by bacillus Calmette-Guerin (BCG) and
lipopolysaccharide (LPS) and rat models of
jaundice by oral alpha-naphthyliso-
thiocyanate (ANIT). Treatment with GPS
injections was administered and both of
enzyme activities of
alanine aminotransferase (ALT) and
aspartate aminotransferase (AST) in the Serum were measured in the models. The serum level of total
bilirubin was determined in the
jaundice models. RESULTS: Compared with those of the untreated models, the
enzyme activities of ALT and AST were significantly reduced in groups with
a 10 day GPS treatment (P<0.001, P<0.05). Higher dosage of GPS showed more conspicuous effects in relieving the
jaundice. CONCLUSION: GPS can be administered as the antagonist against CC14-induced liver injury and offers protection against immune-mediated liver damage.