The potential of preoperative beta-hCG and progesterone levels to predict failure of laparoscopic linear salpingostomy in ectopic pregnancies.

Abstract

STUDY OBJECTIVE:

To estimate the association between preoperative beta-human chorionic gonadotropin (hCG) and progesterone levels, and success of linear salpingostomy in treatment of tubal pregnancy.

DESIGN:

Retrospective case control study (Canadian Task Force classification II-1).

SETTING:

Women's general hospital.

PATIENTS:

Three hundred five women undergoing laparoscopic linear salpingostomy for ectopic pregnancy.

INTERVENTION:

Examination of risk factors for surgical failure of salpingostomy by analyzing corresponding receiver operating curves.

MEASUREMENTS AND MAIN RESULTS:

In 305 women, intervention was successful in 272 and failed in 33, as assessed by either postoperative hemorrhage (16) or rising beta-hCG values (14); 3 women had both. Of 295 patients in whom beta-hCG was evaluated preoperatively, 149 (50.5%) had values of 1000 mU/ml. or less; 75% had progesterone levels of 10 ng/ml or below. No association was found between preoperative beta-hCG and progesterone levels and the success of linear salpingostomy.

CONCLUSION:

Preoperative beta-hCG and progesterone levels are of no significance with regard to success of linear salpingostomy for treatment of tubal pregnancy.

• Authors: Gernot Tews, Thomas Ebner, Cemil Yaman, Werner Pölz, Michael Sommergruber, Johannes Hartl
• Journal: The Journal of the American Association of Gynecologic Laparoscopists (J Am Assoc Gynecol Laparosc) Vol. 9 Issue 4 Pg. 460-3 (Nov 2002) ISSN: 1074-3804 [Print] United States
• PMID: 12386356 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Biomarkers
• Chorionic Gonadotropin, beta Subunit, Human
• Progesterone

Topics

• Adult
• Biomarkers (blood)
• Case-Control Studies
• Chorionic Gonadotropin, beta Subunit, Human (blood, metabolism)
• Confidence Intervals
• Female
• Follow-Up Studies
• Humans
• Predictive Value of Tests
• Pregnancy
• Pregnancy, Ectopic (blood, diagnosis, surgery)
• Preoperative Care
• Probability
• Progesterone (blood, metabolism)
• ROC Curve
• Retrospective Studies
• Salpingostomy (adverse effects, methods)
• Sensitivity and Specificity
• Treatment Outcome