Pathogenic significance of IgA receptor interactions in IgA nephropathy.

Abstract

IgA nephropathy (IgAN), the most common primary glomerulonephritis worldwide, frequently progresses to renal failure. The pathogenesis of this disease involves the deposition of undergalactosylated IgA1 complexes in the glomerular mesangium. How the IgA1 complexes are generated and why they are deposited in the mesangium remains unclear. We propose a model wherein two types of IgA receptors participate in sequential steps to promote the development of IgAN, with FcalphaRI (CD89) being initially involved in the formation of circulating IgA-containing complexes and, subsequently, transferrin receptor (CD71) in mediating mesangial deposition of IgA1 complexes.

• Authors: Renato C Monteiro, Ivan C Moura, Pierre Launay, Toshinao Tsuge, Elie Haddad, Marc Benhamou, Max D Cooper, Michelle Arcos-Fajardo
• Journal: Trends in molecular medicine (Trends Mol Med) Vol. 8 Issue 10 Pg. 464-8 (Oct 2002) ISSN: 1471-4914 [Print] England
• PMID: 12383768 (Publication Type: Journal Article, Review)

Chemical References

• Antigens, CD
• Antigens, Differentiation, B-Lymphocyte
• CD71 antigen
• Fc(alpha) receptor
• Immunoglobulin A
• Macromolecular Substances
• Receptors, Fc
• Receptors, Transferrin

Topics

• Animals
• Antigens, CD (metabolism)
• Antigens, Differentiation, B-Lymphocyte (metabolism)
• Glomerulonephritis, IGA (metabolism)
• Humans
• Immunoglobulin A (metabolism)
• Macromolecular Substances
• Mice
• Mice, Transgenic
• Models, Immunological
• Receptors, Fc (metabolism)
• Receptors, Transferrin