Abstract | BACKGROUND AND PURPOSE: METHODS: We obtained baseline serum samples from patients with chronic coronary heart disease enrolled in the Bezafibrate Infarction Prevention trial (n=3090), which assessed the efficacy of bezafibrate in secondary prevention. Using a prospective nested case-control design, we measured baseline sICAM-1 concentration in sera of patients who developed ischemic stroke during a mean follow-up of 8.2 years (cases, n=134) and in age- and sex-matched controls without any subsequent cardiovascular events (n=134). RESULTS: Baseline serum concentrations of sICAM-1 were significantly higher in cases compared with controls (379 versus 350 ng/mL, P<0.05). sICAM-1 concentration at the highest quartile (>394 ng/mL) was associated with significantly higher relative odds of ischemic stroke compared with the lower concentrations after adjustment for potential confounding variables (relative odds, 2.1; 95% CI, 1.1 to 4.3). After fibrinogen and total white blood cell count were added to the multivariable model, the relative odds were 2.1 (95% CI, 1.1 to 4.2) and 2.2 (95% CI, 1.1 to 4.8), respectively. The risk associated with raised concentrations of sICAM-1 seemed to be highest for large disabling strokes of cardioembolic origin. CONCLUSIONS:
|
Authors | David Tanne, Moti Haim, Valentina Boyko, Uri Goldbourt, Tamar Reshef, Shlomo Matetzky, Yehuda Adler, Yoseph A Mekori, Solomon Behar |
Journal | Stroke
(Stroke)
Vol. 33
Issue 9
Pg. 2182-6
(Sep 2002)
ISSN: 1524-4628 [Electronic] United States |
PMID | 12215584
(Publication Type: Journal Article)
|
Chemical References |
- Biomarkers
- Hypolipidemic Agents
- Intercellular Adhesion Molecule-1
- Fibrinogen
- Bezafibrate
|
Topics |
- Bezafibrate
(therapeutic use)
- Biomarkers
(blood)
- Brain Ischemia
(blood, epidemiology)
- Case-Control Studies
- Chronic Disease
- Cohort Studies
- Comorbidity
- Coronary Disease
(blood, prevention & control)
- Female
- Fibrinogen
(analysis)
- Follow-Up Studies
- Humans
- Hypolipidemic Agents
(therapeutic use)
- Intercellular Adhesion Molecule-1
(blood)
- Israel
(epidemiology)
- Logistic Models
- Male
- Middle Aged
- Predictive Value of Tests
- Prospective Studies
- Randomized Controlled Trials as Topic
(statistics & numerical data)
- Risk
- Risk Assessment
- Risk Factors
- Stroke
(blood, epidemiology)
|