Abstract | OBJECTIVE: DESIGN: The present study was designed as a nested case-control study. METHOD: In this study (nested in the Dutch Bypass Oral anticoagulants or Aspirin Study), 150 patients with graft occlusion were each matched with two randomly selected controls with patent grafts (N = 299) from the same trial. Venous blood samples were drawn from cases and controls, and total plasma homocysteine (tHcy) was determined. Mean serum homocysteine levels and the presence of hyperhomocysteinemia (>95th percentile in healthy individuals) were compared between cases and controls. RESULTS: No significant differences were found between serum levels of homocysteine in patients with and without graft occlusion. The mean plasma homocysteine levels were 14.4 micromol/L and 14.9 micromol/L in the case and control groups, respectively. The resulting mean difference was -0.4 (95% confidence interval [CI], -1.8-0.9). The odds ratio of hyperhomocysteinemia was 0.81 (95% CI, 0.49-1.33). Adjustment for risk factors of graft occlusion did not change these results. CONCLUSIONS: Postoperative raised serum levels of homocysteine proved not to be a risk factor for graft occlusion after infrainguinal bypass grafting.
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Authors | G J de Borst, M J D Tangelder, A Algra, J A Lawson, J D Banga, B C Eikelboom, J A van der Vliet, Dutch BOA (Bypass Oral anticoagulants or Aspirin) Study Group |
Journal | Journal of vascular surgery
(J Vasc Surg)
Vol. 36
Issue 2
Pg. 336-40
(Aug 2002)
ISSN: 0741-5214 [Print] United States |
PMID | 12170215
(Publication Type: Journal Article)
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Topics |
- Aged
- Case-Control Studies
- Female
- Graft Occlusion, Vascular
(blood, etiology)
- Humans
- Hyperhomocysteinemia
(complications)
- Male
- Middle Aged
- Multicenter Studies as Topic
- Randomized Controlled Trials as Topic
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