Abstract | BACKGROUND: METHODS: RESULTS: No difference of total IgE and C(3c) and C(4) complement fractions was found among the three groups. Anti- ioxaglate IgE-RIA was positive in only one patient from group 1. The affinity of drug- IgE binding in the serum of this patient was very low (Kd: 18.7 mM). The level of anti-ICM IgE detected by ioxitalamate- and iomeprol- Sepharose RIA was significantly higher in groups 2 and 3 than in group 1. CONCLUSIONS: The higher histamine release in ischaemic heart disease patients undergoing coronaroangiography is not mediated by IgE or complement activation. Further studies are needed to investigate the implication of histamine release factors.
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Authors | Rosa-Maria Rodriguez, J-L Guéant, I Aimone-Gastin, P Gérard, F Amoghly, A Bellou, Y Jullière, G Faure, N Danchin, A Romano |
Journal | Allergy
(Allergy)
Vol. 57 Suppl 72
Pg. 61-6
( 2002)
ISSN: 0105-4538 [Print] Denmark |
PMID | 12144558
(Publication Type: Journal Article)
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Chemical References |
- Complement C4
- Contrast Media
- Immunoglobulin E
- Complement C3c
- Ioxaglic Acid
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Topics |
- Complement C3c
(analysis)
- Complement C4
(analysis)
- Contrast Media
(adverse effects)
- Coronary Angiography
- Coronary Disease
(diagnostic imaging, immunology)
- Drug Hypersensitivity
(diagnosis, etiology)
- Histamine Release
(drug effects)
- Humans
- Hypersensitivity, Immediate
(diagnosis, etiology)
- Immunoglobulin E
(blood)
- Ioxaglic Acid
(adverse effects)
- Prospective Studies
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