Abstract | AIMS: METHODS: RESULTS: The allele frequencies and the genotype frequencies of these 3 polymorphisms were not different between HD patients and controls. In HD patients, plasma fibrinogen levels were significantly lower in the GG genotype than in the GA genotype, and plasma factor VII activity was significantly higher in the RR genotype than in the RQ genotype. Multiple regression analysis disclosed that CRP and beta- fibrinogen polymorphism were the significant determinants of fibrinogen levels. Plasma PAI-1 levels were not different among the 3 genotypes. The frequency of the A-455 allele was significantly higher in HD patients with CI than in those without CI, and the genotype distribution for beta- fibrinogen differed significantly between the 2 groups. Between the same 2 groups, however, significant differences were found neither in the frequency of the 353Q or 4G allele nor in the genotype distribution for factor VII and PAI-1. No significant differences in the frequency of the G-455, 353Q or 4G alleles, or in the genotype distribution for beta- fibrinogen, factor VII and PAI-1 were observed between patients with IHD and those without IHD. Multiple logistic regression analysis demonstrated that neither polymorphism was associated with CI or IHD. CONCLUSIONS: In HD patients, beta- fibrinogen and factor VII polymorphisms affected plasma levels of fibrinogen and factor VII, respectively. Beta- fibrinogen polymorphism was not an independent but a possible risk factor for CI in HD patients. Further study will be needed to confirm the precise role of 5-fibrinogen polymorphisms in the pathogenesis of CI in HD patients.
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Authors | R Ando, M Doi, K Yamauchi, Y Chida, T Ida, K Endo, H Yanagi, S Tomura |
Journal | Clinical nephrology
(Clin Nephrol)
Vol. 58
Issue 1
Pg. 25-32
(Jul 2002)
ISSN: 0301-0430 [Print] Germany |
PMID | 12141403
(Publication Type: Journal Article)
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Chemical References |
- Plasminogen Activator Inhibitor 1
- Factor VII
- Fibrinogen
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Topics |
- Adult
- Cerebral Infarction
(blood, genetics)
- Factor VII
(genetics, metabolism)
- Female
- Fibrinogen
(genetics, metabolism)
- Gene Frequency
- Genotype
- Humans
- Logistic Models
- Male
- Middle Aged
- Myocardial Ischemia
(blood, genetics)
- Plasminogen Activator Inhibitor 1
(blood, genetics)
- Polymorphism, Genetic
- Renal Dialysis
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