Obesity therapy: altering the energy intake-and-expenditure balance sheet.

Abstract

Obesity is associated with numerous health complications, which range from non-fatal debilitating conditions such as osteoarthritis, to life-threatening chronic diseases such as coronary heart disease, diabetes and certain cancers. The psychological consequences of obesity can range from lowered self-esteem to clinical depression. Despite the high prevalence of obesity and the many advances in our understanding of how it develops, current therapies have persistently failed to achieve long-term success. This review focuses on how fat mass can be reduced by altering the balance between energy intake and expenditure.

• Authors: Vivion E F Crowley, Giles S H Yeo, Stephen O'Rahilly
• Journal: Nature reviews. Drug discovery (Nat Rev Drug Discov) Vol. 1 Issue 4 Pg. 276-86 (Apr 2002) ISSN: 1474-1776 [Print] England
• PMID: 12120279 (Publication Type: Journal Article, Review)

Chemical References

• Carrier Proteins
• Hypothalamic Hormones
• Leptin
• Melanins
• Neuropeptide Y
• Pituitary Hormones
• Receptor, Muscarinic M1
• Receptors, Cell Surface
• Receptors, Corticotropin
• Receptors, Leptin
• Receptors, Melanocortin
• Receptors, Muscarinic
• Receptors, Pituitary Hormone
• melanin-concentrating hormone receptor
• Pro-Opiomelanocortin
• melanin-concentrating hormone

Topics

• Adipose Tissue, Brown (metabolism)
• Carrier Proteins (physiology)
• Energy Intake
• Energy Metabolism
• Humans
• Hypothalamic Hormones (physiology)
• Leptin (physiology)
• Melanins (physiology)
• Neuropeptide Y (physiology)
• Obesity (metabolism, therapy)
• Pituitary Hormones (physiology)
• Pro-Opiomelanocortin (physiology)
• Receptor, Muscarinic M1
• Receptors, Cell Surface
• Receptors, Corticotropin (physiology)
• Receptors, Leptin
• Receptors, Melanocortin
• Receptors, Muscarinic (physiology)
• Receptors, Pituitary Hormone (physiology)
• Transcription, Genetic