Abstract | CONTEXT: SETTING: Fifteen primary pancreatic endocrine tumors, including five insulinomas and 10 non-functioning tumors, along with seven hepatic metastatic pancreatic endocrine tumors. MAIN OUTCOME MEASURES: Quantitative expression levels of cancer associated Sm-like mRNA were measured by real-time PCR. Overexpression was defined as a two-fold or greater value when compared to the expression levels found in normal pancreatic islet cells obtained from healthy donors. RESULTS: In primary tumors, four of the 10 non-functioning pancreatic endocrine tumors were found to overexpress cancer associated Sm-like mRNA (40%). Three of the five (60%) insulinomas also overexpressed cancer associated Sm-like mRNA. In total, cancer associated Sm-like mRNA was overexpressed in seven of 15 primary tumors (47%) and in the majority (71%, 5 of 7) of the hepatic metastases. CONCLUSIONS:
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Authors | Andrew A Gumbs, Claudio Bassi, Patrick S Moore, Massimo Falconi, Isabella Frigerio, Antonella Baron, Lorenzo Piemonti, Irvin Modlin, Aldo Scarpa |
Journal | JOP : Journal of the pancreas
(JOP)
Vol. 3
Issue 4
Pg. 109-15
(Jul 2002)
ISSN: 1590-8577 [Electronic] Italy |
PMID | 12110768
(Publication Type: Case Reports, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- LSM1 protein, human
- MAS1 protein, human
- Proto-Oncogene Mas
- Proto-Oncogene Proteins
- RNA, Neoplasm
- RNA-Binding Proteins
|
Topics |
- Adenoma, Islet Cell
(diagnosis, genetics, metabolism, pathology)
- Adult
- Aged
- Female
- Humans
- Islets of Langerhans
(metabolism)
- Liver Neoplasms
(genetics, metabolism, secondary)
- Male
- Middle Aged
- Pancreatic Neoplasms
(diagnosis, genetics, metabolism, pathology)
- Proto-Oncogene Mas
- Proto-Oncogene Proteins
(biosynthesis, genetics)
- RNA, Neoplasm
(biosynthesis)
- RNA-Binding Proteins
- Tumor Cells, Cultured
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