[Induction of stomach tumors in rats by N-methyl-N-nitroso-N1-nitroguanidine].

Abstract

N-methyl-N-nitroso-N'-nitroguanidine was administered as drinking water to Wistar strain and non-inbred male rats in the dosage of 100 mKg/ml for 7 months, Adenocarcinomas of the stomach were produced in about 70% of rats. The first tumors in the glandular stomach were noticed in 10-12.5 months. Studies of the kinetics of morphological changes indicated that MNNG induced a damage to the mucous membrane, subsequent regenerative hyperplasia, adenomatous hyperplasia with cellular and structural atypism, atrophy, pylorization of the mucosa and development of gastric adenocarcinomas.

• Authors: L A Kartasheva, A I Bykorez
• Journal: Voprosy onkologii (Vopr Onkol) Vol. 21 Issue 12 Pg. 50-5 ( 1975) ISSN: 0507-3758 [Print] Russia (Federation)
• Vernacular Title: Induktsiia opukholeĭ zheludka u krys N-metil-N-nitroso-Nl-nitroguanidinom
• PMID: 1210129 (Publication Type: English Abstract, Journal Article)

Chemical References

• Nitrosoguanidines
• Methylnitronitrosoguanidine

Topics

• Adenocarcinoma (chemically induced, pathology)
• Animals
• Gastric Mucosa (pathology)
• Male
• Methylnitronitrosoguanidine
• Nitrosoguanidines
• Rats
• Stomach Neoplasms (chemically induced, pathology)