Abstract |
The immunogenicity of a Japanese purified chick embryo cell culture rabies vaccine (PCECV) was examined. Serum samples were obtained from 86 subjects after pre-exposure or post-exposure prophylaxis. Rabies antibody titres were determined by neutralization test and enzyme-linked immunosorbent assay (ELISA). Titres higher than 0.5 international units (IU)/ml were demonstrated by neutralization test in all the 19 subjects after three-time pre-exposure immunization on days 0, 30 and 180. Titres higher than 0.5IU/ml were also demonstrated by neutralization test in all the 23 subjects after four-time post-exposure immunization on days 0, 3, 7 and 14. There was a correlation between neutralization and ELISA antibody titres (r=0.697); however, neutralization titers were higher than ELISA titres for most of the samples. The results suggest that current Japanese rabies vaccine induces recommended levels of neutralizing antibodies after pre- and post-exposure prophylaxes.
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Authors | Yohko T Arai, Mikio Kimura, Yoshihiro Sakaue, Atsuo Hamada, Ken-Ichiro Yamada, Mikio Nakayama, Tomohiko Takasaki, Ichiro Kurane |
Journal | Vaccine
(Vaccine)
Vol. 20
Issue 19-20
Pg. 2448-53
(Jun 07 2002)
ISSN: 0264-410X [Print] Netherlands |
PMID | 12057599
(Publication Type: Journal Article)
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Chemical References |
- Antibodies, Viral
- Rabies Vaccines
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Topics |
- Antibodies, Viral
(biosynthesis)
- Enzyme-Linked Immunosorbent Assay
- Humans
- Neutralization Tests
- Rabies Vaccines
(administration & dosage, immunology)
- Rabies virus
(immunology)
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