Increase of brain oxidative stress in mild cognitive impairment: a possible predictor of Alzheimer disease.

Abstract

BACKGROUND:

The isoprostane 8,12-iso-iPF(2alpha)-VI, a specific marker of in vivo lipid peroxidation, is increased in Alzheimer disease (AD). The pathological changes associated with AD have a long silent phase before the appearance of clinical symptoms. Several studies have shown that AD is preceded by a prodromal phase characterized by mild cognitive impairment (MCI).

OBJECTIVE:

To investigate levels of this biomarker in subjects with MCI.

DESIGN AND MAIN OUTCOME MEASURES:

Using gas chromatography-mass spectrometry analysis, we measured 8,12-iso-iPF(2alpha)-VI levels in urine, plasma, and cerebrospinal fluid of patients with AD, subjects with MCI, and cognitively normal elderly subjects.

SETTING AND PATIENTS:

Subjects attending the Memory Disorders Clinic.

RESULTS:

We found significantly higher 8,12-iso-iPF(2alpha)-VI levels in cerebrospinal fluid, plasma, and urine of subjects with MCI compared with cognitively normal elderly subjects.

CONCLUSIONS:

These results imply that individuals with MCI have increased brain oxidative damage before the onset of symptomatic dementia. Measurement of this isoprostane may identify a subgroup of patients with MCI with increased lipid peroxidation who are at increased risk to progress to symptomatic AD.

• Authors: Domenico Praticò, Christopher M Clark, Feyan Liun, Joshua Rokach, Virginia Y-M Lee, John Q Trojanowski
• Journal: Archives of neurology (Arch Neurol) Vol. 59 Issue 6 Pg. 972-6 (Jun 2002) ISSN: 0003-9942 [Print] United States
• PMID: 12056933 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Topics

• Adult
• Aged
• Aged, 80 and over
• Alzheimer Disease (diagnosis, metabolism, psychology)
• Analysis of Variance
• Brain (metabolism)
• Cognition Disorders (metabolism, psychology)
• Female
• Humans
• Lipid Peroxidation (physiology)
• Male
• Middle Aged
• Oxidative Stress (physiology)
• Predictive Value of Tests