HLA-B35 association with nephritis in Henoch-Schönlein purpura.

Abstract

OBJECTIVE:

To investigate the implications of the HLA-B locus in the susceptibility to Henoch-Schönlein purpura (HSP) and determine if there are associations with renal and gastrointestinal (GI) manifestations of the disease.

METHODS:

A retrospective study was performed on an unselected population of patients with HSP from Northwest Spain. Forty-eight Caucasian patients (24 women), 11 of them older than 20 years, were studied. Patients and ethnically matched controls were HLA-B genotyped from DNA using molecular based methods.

RESULTS:

When patients with HSP were compared with matched controls, no differences in HLA-B frequencies were observed. No HLA-B associations with GI manifestations were observed. In contrast, an increased frequency of HLA-B35 was observed in patients with renal manifestations (10 of 31) compared to those without (0 of 17). No significant distortions in frequency were seen for any other HLA-B alleles with HSP subgroups.

CONCLUSION:

Our results support a role of HLA-B35 in the susceptibility for nephritis in unselected patients with HSP.

• Authors: Mahsa M Amoli, Wendy Thomson, Ali H Hajeer, Maria C Calviño, Carlos Garcia-Porrua, William E R Ollier, Miguel A Gonzalez-Gay
• Journal: The Journal of rheumatology (J Rheumatol) Vol. 29 Issue 5 Pg. 948-9 (May 2002) ISSN: 0315-162X [Print] Canada
• PMID: 12022355 (Publication Type: Journal Article)

Chemical References

• HLA-B35 Antigen

Topics

• Adult
• Child
• Female
• Genotype
• HLA-B35 Antigen (genetics)
• Humans
• IgA Vasculitis (genetics, immunology)
• Linkage Disequilibrium
• Male
• Nephritis (genetics, immunology)
• Phenotype
• Retrospective Studies