The role of inflammatory cytokines in Meigs' syndrome.

Abstract

BACKGROUND:

Inflammatory cytokines are known to induce capillary leakage and third-space fluid accumulation in numerous gynecologic and nongynecologic disorders. This study aimed to assess their role in Meigs' syndrome.

CASE:

Evaluation of serum, peritoneal, and pleural fluids retrieved from a patient suffering from Meigs' syndrome revealed high interleukin (IL)-1beta, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha levels. After surgical removal of the ovarian tumor and with resolution of ascites and hydrothorax, serum levels of IL-1beta, IL-6, and IL-8 declined, whereas tumor necrosis factor-alpha levels remained high.

CONCLUSION:

The correlation between these inflammatory cytokines and the clinical course of Meigs' syndrome suggests their involvement in the formation of ascites and hydrothorax in this disorder.

• Authors: Yoram Abramov, Shaoul O Anteby, Sozos J Fasouliotis, Vivian Barak
• Journal: Obstetrics and gynecology (Obstet Gynecol) Vol. 99 Issue 5 Pt 2 Pg. 917-9 (May 2002) ISSN: 0029-7844 [Print] United States
• PMID: 11975958 (Publication Type: Case Reports, Journal Article)

Chemical References

• Cytokines
• Interleukin-1
• Interleukin-6
• Interleukin-8
• Tumor Necrosis Factor-alpha

Topics

• Cytokines (blood)
• Female
• Humans
• Interleukin-1 (blood)
• Interleukin-6 (blood)
• Interleukin-8 (blood)
• Meigs Syndrome (immunology, surgery)
• Postmenopause
• Tumor Necrosis Factor-alpha (analysis)