Abstract | BACKGROUND: METHODS: We recruited 48 patients about to have major abdominal surgery. We present data for 34 patients: 27 who received patient-controlled intravenous morphine and 7 who received epidural opioid. Treatment was randomized to either nCPAP or conventional therapy with an oxygen mask. Alternate periods of administration of air and 35% oxygen were used in both groups. If the oxygen saturation as measured by pulse oximetry was consistently <90% on air, the patient was withdrawn from the study. We measured sleep, arousals, oxygenation, episodes of desaturation, and disturbances of respiration. Values are given as median and quartiles. RESULTS: The median proportion of time awake was 65% (45-79%) among control patients and 74% (55-87%) among those undergoing nCPAP. Oxygen administration did not affect the sleep pattern. The median frequency of arousals per hour of sleep was very similar in each group: during air breathing from nCPAP, 125 (76-187), and during air breathing by mask, 116 (84-187). Oxygen therapy had no effect. Oxygenation and hypoxemic events were not improved by nCPAP. Oxygen therapy improved oxygenation and reduced but did not eliminate episodes of desaturation. CONCLUSIONS: Nasal CPAP does not improve sleep and oxygenation or reduce hypoxemic events in the first night after major abdominal surgery.
|
Authors | Gordon B Drummond, Kristina Stedul, Ruth Kingshott, Karen Rees, Alastair F Nimmo, Peter Wraith, Neil J Douglas |
Journal | Anesthesiology
(Anesthesiology)
Vol. 96
Issue 4
Pg. 817-26
(Apr 2002)
ISSN: 0003-3022 [Print] United States |
PMID | 11964587
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Chemical References |
|
Topics |
- Abdomen
(surgery)
- Adult
- Aged
- Arousal
- Female
- Humans
- Hypoxia
(therapy)
- Male
- Middle Aged
- Oxygen
(therapeutic use)
- Positive-Pressure Respiration
- Postoperative Complications
(therapy)
- Sleep Wake Disorders
(therapy)
|