Antitumor activity of compounds isolated from leaves of Eriobotrya japonica.

Abstract	In a search for possible antitumor agents from natural sources, megastigmane glycosides and polyphenolic constituents isolated from the leaves of Eriobotrya japonica (Rosaceae) were found to inhibit the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced activation of Epstein-Barr virus early antigen in Raji cells. Roseoside and procyanidin B-2 were among the active compounds found in an in vitro assay; these compounds were further assessed for antitumor activity in vivo in a two-stage carcinogenesis assay on mouse skin. Roseoside significantly delayed carcinogenesis induced by peroxynitrite (initiator) and TPA (promoter), and its potency was comparable to that of a green tea polyphenol, (-)-epigallocatechin 3-O-gallate, in the same assay.
Authors	Hideyuki Ito, Eri Kobayashi, Shu-Hua Li, Tsutomu Hatano, Daigo Sugita, Naoki Kubo, Susumu Shimura, Yoshio Itoh, Harukuni Tokuda, Hoyoku Nishino, Takashi Yoshida
Journal	Journal of agricultural and food chemistry (J Agric Food Chem) Vol. 50 Issue 8 Pg. 2400-3 (Apr 10 2002) ISSN: 0021-8561 [Print] United States
PMID	11929303 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antigens, Viral Antineoplastic Agents Biflavonoids Carcinogens Glucosides Norisoprenoids Proanthocyanidins Tea roseoside Peroxynitrous Acid procyanidin B procyanidin 9,10-Dimethyl-1,2-benzanthracene Catechin epigallocatechin gallate Tetradecanoylphorbol Acetate
Topics	9,10-Dimethyl-1,2-benzanthracene Animals Antigens, Viral (analysis) Antineoplastic Agents (isolation & purification, therapeutic use) Biflavonoids Carcinogens Catechin (analogs & derivatives, isolation & purification, therapeutic use) Female Glucosides (isolation & purification, therapeutic use) Herpesvirus 4, Human (genetics, growth & development, immunology) Humans Mice Mice, Inbred ICR Nasopharyngeal Neoplasms (virology) Norisoprenoids Peroxynitrous Acid Plant Leaves (chemistry) Proanthocyanidins Rosaceae (chemistry) Skin Neoplasms (chemically induced, drug therapy) Tea (chemistry) Tetradecanoylphorbol Acetate (pharmacology) Virus Activation (drug effects)

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