[Advantages of capoten chronotherapy of patients with hypertension in an outpatient setting].

Abstract

AIM:

To compare the efficiency of a short course of preventive chronotherapy and traditional therapy with capoten in an outpatient setting.

MATERIAL AND METHODS:

Forty-two patients with stage II essential hypertension were divided into 2 groups: 20 controls were treated with capoten in a dose of 12.5-50 mg 3 times a day and 22 received capoten once a day in the same single dose 1.5-2 h before arterial pressure (AP) acrophase. Central hemodynamics was studied by echocardiography, regional hemodynamics by reheoencephalography before and at the end of therapy.

RESULTS:

In the control group AP normalized after capoten therapy in 3 patients, decreased by at least 10% but did not normalize in 9, and did not change in 8 patients. The results in the chronotherapy group were as follows: AP normalized in 5, decreased by at least 15% in 13, and did not change in 4 patients. Normalization of daily profiles of hemodynamic values and more favorable shifts in the cerebral bloodflow were more often seen in patients who received chronotherapy.

CONCLUSION:

Capoten chronotherapy of patients with essential hypertension, carried out in an outpatient setting, is obviously preferable to traditional treatment: no side effects were observed and a better hypotensive effect was attained with lower total dose.

• Authors: S D Beliaev, R M Zaslavskaia
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 74 Issue 1 Pg. 18-21 ( 2002) ISSN: 0040-3660 [Print] Russia (Federation)
• Vernacular Title: Preimushchestva khronoterapii kapotenom bol'nykh gipertonicheskoĭ bolezn'iu v ambulatornykh usloviiakh.
• PMID: 11878051 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article)

Chemical References

• Antihypertensive Agents
• Captopril

Topics

• Adult
• Aged
• Ambulatory Care
• Antihypertensive Agents (administration & dosage, adverse effects, therapeutic use)
• Captopril (administration & dosage, adverse effects, therapeutic use)
• Chronotherapy
• Female
• Humans
• Hypertension (drug therapy)
• Male
• Middle Aged