Abstract | INTRODUCTION: METHODS: Retrospective analysis of the data sheet of pretreated patients suffering from intractable pain and treated with gabapentin as a third line drug at a university pain clinic. Pain intensity (visual analogue scale, VAS 0 -10 cm), pain characteristics, diagnosis, pre- and co-treatment, and side effects were assessed. Response to treatment was defined as a 50% reduction in pain or a pain intensity of VAS </= 3. RESULTS: 99 patients were included. Approximately half the patients (n = 49) responded to gabapentin. Patients suffering from neuropathic pain showed a higher response rate (60%) compared to patients with muscle-sceletal pain (35%). Allodynia was twice as high in the responders (35%) compared to the non-responders (18%) before treatment. No serious side effects were reported. CONCLUSION:
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Authors | B Gustorff, G Nahlik, A Spacek, H G Kress |
Journal | Schmerz (Berlin, Germany)
(Schmerz)
Vol. 16
Issue 1
Pg. 9-14
(Feb 2002)
ISSN: 0932-433X [Print] Germany |
Vernacular Title | Gabapentin in der Therapie chronischer therapieresistenter Schmerzen. Erste Erfahrungen bei 99 Patienten. |
PMID | 11845336
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Acetates
- Amines
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents, Non-Steroidal
- Cyclohexanecarboxylic Acids
- Placebos
- Serotonin Uptake Inhibitors
- Triazines
- Amitriptyline
- Carbamazepine
- gamma-Aminobutyric Acid
- Gabapentin
- Lamotrigine
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Topics |
- Acetates
(administration & dosage, adverse effects, therapeutic use)
- Amines
- Amitriptyline
(administration & dosage, therapeutic use)
- Analgesics
(administration & dosage, adverse effects, therapeutic use)
- Analgesics, Non-Narcotic
(administration & dosage, therapeutic use)
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage, therapeutic use)
- Carbamazepine
(administration & dosage, therapeutic use)
- Chronic Disease
- Cyclohexanecarboxylic Acids
- Drug Therapy, Combination
- Gabapentin
- Humans
- Lamotrigine
- Pain, Intractable
(diagnosis, drug therapy)
- Placebos
- Retrospective Studies
- Selective Serotonin Reuptake Inhibitors
(administration & dosage, therapeutic use)
- Time Factors
- Triazines
(administration & dosage, therapeutic use)
- gamma-Aminobutyric Acid
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