Abstract |
We reported previously that high levels of vascular endothelial growth factor ( VEGF) were associated with shorter survival in adult acute myeloid leukemia (AML) patients. In this study, cellular VEGF and its receptor, VEGF-R2 ( kinase domain receptor (KDR)), were analyzed in 45 pediatric AML patients using Western blot and solid-phase radioimmunoassay (RIA). Cellular VEGF levels were significantly lower in pediatric AML compared to adult AML patients. In contrast, there was no significant difference in VEGF-R2 levels between adult and pediatric AML. Higher VEGF and VEGF-R2 levels in pediatric AML patients correlated with higher white blood cell (WBC). Unlike in adults, VEGF and VEGF-R2 levels in pediatric AML patients did not correlate with survival. This data suggest that the role of VEGF and its receptor VEGF-R2 in pediatrics AML may be different from that in adult AML.
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Authors | Sima Jeha, Franklin O Smith, Elihu Estey, Yu Shen, Diane Liu, Taghi Manshouri, Maher Albitar |
Journal | Leukemia research
(Leuk Res)
Vol. 26
Issue 4
Pg. 399-402
(Apr 2002)
ISSN: 0145-2126 [Print] England |
PMID | 11839384
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Endothelial Growth Factors
- Lymphokines
- Receptors, Growth Factor
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors
- Receptor Protein-Tyrosine Kinases
- Receptors, Vascular Endothelial Growth Factor
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Topics |
- Acute Disease
- Adolescent
- Adult
- Age Factors
- Bone Marrow
(metabolism)
- Child
- Child, Preschool
- Endothelial Growth Factors
(metabolism)
- Female
- Humans
- Infant
- Leukemia, Myeloid
(metabolism, physiopathology)
- Lymphokines
(metabolism)
- Male
- Prognosis
- Receptor Protein-Tyrosine Kinases
(metabolism)
- Receptors, Growth Factor
(metabolism)
- Receptors, Vascular Endothelial Growth Factor
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors
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