Clinical significance of p53, MDM2 and bcl-2 expression in transitional cell carcinoma of the bladder.

Abstract

We investigated the prognostic and predictive relevance of p53, MDM2, and bcl-2 protein expression in patients with transitional cell carcinoma (TCC) of the bladder. The expression of p53, MDM2 and bcl-2 protein was studied by immunohistochemical methods in paraffin-embedded specimens from 119 patients whose clinicopathologic data confirmed TCC of the bladder. Multivariate analyses of prognostic factors were performed, and correlations with classical clinicopathologic parameters were examined. Sixty-one, 12, and 17% of cases were considered positive for expression of p53, MDM2 and bcl-2, respectively. p53 expression correlated with stage (p=0.0209), but not MDM2 and bcl-2 with any clinicopathologic parameters. In Cox's regression analysis, staging demonstrated a statistically worse prognosis (hazard ratio 1.636; p=0.0059) while bcl-2 (hazard ratio 0.179; p=0.0474) expression showed favorable prognosis in stage T2-4 invasive TCC of the bladder. Co-expression with p53/MDM2 (hazard ratio 0.367; p=0.0401) and p53/bcl-2 (hazard ratio 3.487; p=0.0111) overexpression were associated with favorable and unfavorable prognosis in stage T2-4 invasive TCC of the bladder, respectively. Our results indicate that staging is the most useful parameter to predict clinical outcome in patients with TCC of the bladder. Determinations of bcl-2 and co-expression p53/MDM2 and p53/bcl-2 may be useful for predicting tumor behavior and prognosis in stage T2-4 invasive type TCC of the bladder.

• Authors: T Uchida, S Minei, J-P Gao, C Wang, T Satoh, S Baba
• Journal: Oncology reports (Oncol Rep) 2002 Mar-Apr Vol. 9 Issue 2 Pg. 253-9 ISSN: 1021-335X [Print] Greece
• PMID: 11836589 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Nuclear Proteins
• Proto-Oncogene Proteins
• Proto-Oncogene Proteins c-bcl-2
• Tumor Suppressor Protein p53
• MDM2 protein, human
• Proto-Oncogene Proteins c-mdm2

Topics

• Adult
• Aged
• Aged, 80 and over
• Carcinoma, Transitional Cell (metabolism, pathology)
• Female
• Humans
• Immunoenzyme Techniques
• Male
• Middle Aged
• Neoplasm Staging
• Nuclear Proteins
• Prognosis
• Proto-Oncogene Proteins (metabolism)
• Proto-Oncogene Proteins c-bcl-2 (metabolism)
• Proto-Oncogene Proteins c-mdm2
• Retrospective Studies
• Risk Factors
• Survival Rate
• Tumor Suppressor Protein p53 (metabolism)
• Urinary Bladder Neoplasms (metabolism, pathology)