Abstract |
Recent studies with PEG liposomes in patients have consistently shown that liposomes can induce side effects ( flushing, tightness of the chest). Furthermore, the blood clearance of PEG liposomes was shown to be dose-dependent: at lipid doses lower than 1 micromol/kg, PEG liposomes do not show the long-circulation property but instead are cleared relatively rapidly from the bloodstream. Another remarkable observation was that repeated injections of PEG liposomes led to significant pharmacokinetic changes: the circulatory half-life of a second dose of radiolabeled PEG liposomes dramatically decreased when given from 5 days to up to 4 weeks after a first injection. In these three unexpected phenomena, proteins of the complement system seem to play a key role. Therefore, one has to consider that PEG liposomes are not inert drug-carrying vehicles in vivo. Pharmacological effects can occur, induced solely by using liposomal particles irrespective of the drug content.
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Authors | P Laverman, O C Boerman, Oyen WJG, Corstens FHM, G Storm |
Journal | Critical reviews in therapeutic drug carrier systems
(Crit Rev Ther Drug Carrier Syst)
Vol. 18
Issue 6
Pg. 551-66
( 2001)
ISSN: 0743-4863 [Print] United States |
PMID | 11789675
(Publication Type: Journal Article, Review)
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Chemical References |
- Antineoplastic Agents
- Liposomes
- Polyethylene Glycols
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Topics |
- Animals
- Antineoplastic Agents
(administration & dosage)
- Complement Activation
(immunology)
- Dose-Response Relationship, Drug
- Drug Delivery Systems
(adverse effects)
- Half-Life
- Humans
- Liposomes
(administration & dosage, adverse effects, immunology, pharmacokinetics)
- Macrophage Activation
(immunology)
- Polyethylene Glycols
(administration & dosage, adverse effects, pharmacokinetics)
- Radioimmunodetection
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