Abstract | OBJECTIVE: METHODS: A reverse transcription-polymerase chain reaction (RT-PCR) method was utilized to examine and quantitate MCP-1 mRNA expressions and levels in the eutopic endometrium. Thirty patients with endometriosis were included as study group, and 20 patients without endometriosis selected as control group. RESULTS: 26 (87%) of 30 samples of endometrium from patients with endometriosis expressed MCP-1 mRNA, 19 of which were strong expression, while 15 (75%) of 20 samples of endometrium from patients without endometriosis express MCP-1 mRNA (P > 0.05). When endometriosis were grouped by Revised American Fertility Society (RAFS) stages, there was no obvious correlation between stage and MCP-1 mRNA expression level (P > 0.05). Semi-quantitative PCR showed the expression level of MCP-1 in endometrium of patients with endometriosis were higher than those of patients without endometriosis (0.746 +/- 0.345 Vs 0.460 +/- 0.341 respectively, P < 0.05). CONCLUSIONS: The MCP-1 mRNA is over expressed in the eutopic endometrium from patients with endometriosis, which may play some roles on the pathogenesis of endometriosis.
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Authors | X Tan, J Lang, D Liu |
Journal | Zhonghua fu chan ke za zhi
(Zhonghua Fu Chan Ke Za Zhi)
Vol. 36
Issue 2
Pg. 89-91
(Feb 2001)
ISSN: 0529-567X [Print] China |
PMID | 11783354
(Publication Type: English Abstract, Journal Article)
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Chemical References |
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Topics |
- Adult
- Chemokine CCL2
(biosynthesis)
- Choristoma
(metabolism)
- Endometriosis
(metabolism)
- Endometrium
- Female
- Humans
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