Abstract | OBJECTIVE: To characterize serial computed tomography (CT) findings of pulmonary injury after a uniform regimen of concurrent chemo- radiotherapy in inoperable non-small cell lung cancer, and to compare the radiation-induced lung toxicity with other concurrent chemo-radiation regimens. METHODS: RESULTS: Seventeen (81%) patients had characteristic CT findings of radiation-induced pulmonary damage, which were confined to the radiation ports. Although patchy nonhomogeneous and air-space opacities characterized acute radiation pneumonitis, and homogeneous opacities with loss of volume were typical for chronic fibrosis, ground-glass opacities were found frequently in both phases. Acute radiation pneumonitis grade 1 was seen in 29% and grade 2 in 9.5%. Chronic radiation fibrosis grades 1, 2 and 3 were found in 14%, 33% and 19% of the patients respectively. Median survival time was 13 months. CONCLUSION: CT enables detailed evaluation of radiation-induced pulmonary injury after concurrent chemo-radiation for inoperable non-small cell lung cancer. Although survival time with the present regimen is comparable to other concurrent chemo-radiation regimens, a high incidence of radiation injury was found, though the severity was not life threatening.
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Authors | G Aviram, E Yu, P Tai, M S Lefcoe |
Journal | Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes
(Can Assoc Radiol J)
Vol. 52
Issue 6
Pg. 385-91
(Dec 2001)
ISSN: 0846-5371 [Print] United States |
PMID | 11780548
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects, therapeutic use)
- Carcinoma, Non-Small-Cell Lung
(diagnostic imaging, drug therapy, radiotherapy)
- Chemotherapy, Adjuvant
- Chronic Disease
- Cisplatin
(administration & dosage, adverse effects)
- Combined Modality Therapy
- Female
- Follow-Up Studies
- Humans
- Lung Neoplasms
(diagnostic imaging, drug therapy, radiotherapy)
- Male
- Middle Aged
- Radiation Pneumonitis
(diagnostic imaging)
- Radiography
- Vinblastine
(administration & dosage, adverse effects)
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