Abstract | BACKGROUND AND PURPOSE: METHODS: Genotype analysis for factor XIII subunit A Val34Leu, Tyr204Phe, and Pro564Leu and for PAI-1 -675 4G/5G was performed in a population-based case-control study of 42 white women aged <45 years with nonfatal hemorrhagic stroke and 345 demographically similar control subjects. RESULTS: Compared with the respective homozygous wild-type genotypes, the Tyr204/Phe204 genotypes (age-adjusted odds ratio [OR] 2.9, 95% 95% CI 1.1 to 7.5) and the Leu564/Leu564 genotype (OR 4.3, 95% CI 1.4 to 13.7) were each associated with an increased risk of nonfatal hemorrhagic stroke. The risk estimate associated with the Phe204 variant was highest in women with subarachnoid hemorrhage and in nonsmokers, whereas the risk estimate of the Leu564/Leu564 genotype was highest in women with intracerebral hemorrhage and in smokers. Women who carried either the Phe204 allele or the Leu564/Leu564 genotype in combination with the PAI-1 5G/5G genotype had a nearly 20-fold increased risk of hemorrhagic stroke (OR 18.9, 95% CI 3.8 to 95.1). CONCLUSIONS:
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Authors | A P Reiner, S M Schwartz, M B Frank, W T Longstreth Jr, L A Hindorff, G Teramura, F R Rosendaal, L K Gaur, B M Psaty, D S Siscovick |
Journal | Stroke
(Stroke)
Vol. 32
Issue 11
Pg. 2580-6
(Nov 2001)
ISSN: 1524-4628 [Electronic] United States |
PMID | 11692020
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Plasminogen Activator Inhibitor 1
- Factor XIIIa
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Topics |
- Adolescent
- Adult
- Alleles
- Case-Control Studies
- Cerebral Hemorrhage
(diagnosis, ethnology, genetics)
- Factor XIIIa
(genetics)
- Female
- Genetic Predisposition to Disease
- Genotype
- Humans
- Linkage Disequilibrium
- Plasminogen Activator Inhibitor 1
(genetics)
- Polymorphism, Genetic
- Polymorphism, Single Nucleotide
- Stroke
(diagnosis, ethnology, genetics)
- White People
(genetics)
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