Highly active antiretroviral therapy associated with improved anemia among HIV-infected women.

Abstract

Anemia is common during human immunodeficiency virus (HIV) infection and is associated with increased mortality. We conducted a study to examine the impact of highly active antiretroviral therapy (HAART) on anemia in a multicenter cohort of HIV-positive women, the Human Immunodeficiency Virus Epidemiology Research (HER) Study. Among women receiving HAART (n = 188), non-HAART monotherapy or combination antiretroviral therapy (ART) (n = 111), or who had no reported treatment (n = 62), the prevalence of anemia (hemoglobin, <120 g/L) at baseline was 38.3, 36.9, and 43.6%, respectively (p = 0.58) and at 1-year follow-up was 26.1%, 36.9%, 45.2%, respectively (p = 0.01); mean hemoglobin at baseline was 125 +/- 16, 122 +/- 16, and 122 +/- 18 g/L, respectively (p = 0.29) and at 1-year follow-up was 128 +/- 14, 123 +/- 16, and 119 +/- 20 g/L, respectively (p < 0.0001). Adjusted linear regression models showed that HAART was associated with an increase of hemoglobin of 0.20 g/L per month (p = 0.007). After 1 year of treatment, HAART was associated with a 32% reduction in anemia among HIV-infected women (p = 0.01), whereas there was no significant change in the prevalence of anemia among those on non-HAART ART or those who had no reported treatment. HAART is associated with a large reduction in anemia among HIV-infected women.

• Authors: R D Semba, N Shah, R S Klein, K H Mayer, P Schuman, L I Gardner, D Vlahov, HER (Human Immunodeficiency Virus Epidemiology Research) Study Group
• Journal: AIDS patient care and STDs (AIDS Patient Care STDS) Vol. 15 Issue 9 Pg. 473-80 (Sep 2001) ISSN: 1087-2914 [Print] United States
• PMID: 11587633 (Publication Type: Journal Article, Multicenter Study, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Hemoglobins

Topics

• Adult
• Anemia (epidemiology, etiology)
• Antiretroviral Therapy, Highly Active
• Baltimore (epidemiology)
• Cohort Studies
• Cross-Sectional Studies
• Female
• HIV Infections (complications, drug therapy)
• Hemoglobins (metabolism)
• Humans
• Michigan (epidemiology)
• New York City (epidemiology)
• Prevalence
• Rhode Island (epidemiology)
• Women's Health