Abstract |
The effects of three subcutaneous injections of 3 nmol/100 g body weight of the cholecystokinin type 2 ( CCK2) receptor agonist pentagastrin on adrenocorticotrophic hormone ( ACTH) and corticosterone secretion and proliferative activity of regenerating rat adrenal cortex were investigated. Pentagastrin did not alter either ACTH and corticosterone plasma concentrations or the adrenal mitotic index at day 5 of regeneration. In contrast, it increased (by about 50%) the adrenal mitotic index at day 8 of regeneration, and the effect was blocked by the simultaneous administration of equimolar doses of the CCK2-receptor antagonist PD-135,158. It is suggested that the activation of CCK2 receptors exerts a growth promoting action on the regenerating rat adrenal cortex.
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Authors | A Hochól, R de Caro, N Jedrzejczak, A Markowska, M Trejter, G G Nussdorfer, L K Malendowicz |
Journal | Cytobios
(Cytobios)
Vol. 106 Suppl 1
Pg. 119-24
( 2001)
ISSN: 0011-4529 [Print] England |
PMID | 11534823
(Publication Type: Journal Article)
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Chemical References |
- Anti-Inflammatory Agents
- Adrenocorticotropic Hormone
- Pentagastrin
- Corticosterone
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Topics |
- Adrenal Cortex
(cytology, drug effects, physiology)
- Adrenocorticotropic Hormone
(blood, metabolism)
- Animals
- Anti-Inflammatory Agents
(blood)
- Corticosterone
(blood, metabolism)
- Female
- Mitosis
- Mitotic Index
- Pentagastrin
(pharmacology)
- Rats
- Rats, Wistar
- Regeneration
(drug effects)
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