Mass vaccination of children with pertussis toxoid--decreased incidence in both vaccinated and nonvaccinated persons.

Abstract

During 1979-1995, there was no vaccination against pertussis in Sweden. With the aim of studying the epidemiology and transmission of pertussis, mass vaccination with pertussis toxoid of children born during the 1990s was instituted in the Göteborg area (population, 778,597) in 1995. Infants were offered 3 doses of pertussis toxoid combined with diphtheria and tetanus toxoids. Children aged > or =1 year were offered 3 doses of pertussis toxoid alone. From June 1995 through February 1999, 167,810 doses of pertussis toxoid were given to 61,219 children born during the 1990s (56% received 3 doses). The number of Bordetella pertussis isolates per year declined from 1214 (1993-1995) to 64 (January 1997 through June 1999; P<.0001), and hospitalizations due to pertussis declined from 62 to 5 (P<.0001). Significant decreases in B. pertussis isolates and hospitalizations occurred in all age groups, including adults and nonvaccinated infants. Thus, mass vaccination of children with pertussis toxoid decreases spread of B. pertussis in the population.

• Authors: J Taranger, B Trollfors, E Bergfors, N Knutsson, V Sundh, T Lagergård, L Lind-Brandberg, G Zackrisson, J White, H Cicirello, J Fusco, J B Robbins
• Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (Clin Infect Dis) Vol. 33 Issue 7 Pg. 1004-10 (Oct 01 2001) ISSN: 1058-4838 [Print] United States
• PMID: 11528572 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Bacterial
• Diphtheria-Tetanus-Pertussis Vaccine
• Pertussis Vaccine
• Toxoids
• pertussis toxoid

Topics

• Adolescent
• Antibodies, Bacterial (blood)
• Bordetella pertussis (immunology, isolation & purification)
• Child
• Child, Preschool
• Diphtheria-Tetanus-Pertussis Vaccine (administration & dosage)
• Humans
• Incidence
• Infant
• Pertussis Vaccine (administration & dosage, immunology)
• Sweden (epidemiology)
• Toxoids (administration & dosage, immunology)
• Vaccination
• Whooping Cough (epidemiology, microbiology, prevention & control, transmission)