Abstract |
We reported previously that vitamin D deficiency is a causal mechanism of postoperative tetany in patients with Graves' disease. The aim of the present study was to determine the prevalence of vitamin D deficiency by reviewing serum 25( OH)D levels in 208 patients with Graves' disease (146 women, 62 men) during a 1 year period. Serum 25( OH)D levels were significantly lower (p < 0.001) in female Graves' patients (31.8 +/- 13.3 nmol/l) than in male patients (41.3 +/- 15.0 nmol/l). Vitamin D deficiency (defined as a serum 25( OH)D value below 25 nmol/l) was found in 40% of female patients and in 18% of male patients (p < 0.005). There was a significant seasonal variation in the 25( OH)D concentrations in female patients [amplitude 6.38 (95% CI, 5.42-7.56)], with values below 25 nmol/l found in 58% of female patients during the winter months. There were significant (p < 0.001) differences in serum 25( OH)D levels between age groups in the female patients. The concentrations were lowest in patients in their twenties (25.1 +/- 8.2 nmol/l) and highest in patients in their fifties and sixties (43.2 +/- 13.7 nmol/l). Serum 25( OH)D concentrations might be monitored in patients with Graves' disease during antithyroid drug therapy, and vitamin D and/or calcium supplements are recommended for patients with vitamin D deficiency.
|
Authors | H Yamashita, S Noguchi, K Takatsu, E Koike, T Murakami, S Watanabe, S Uchino, H Yamashita, H Kawamoto |
Journal | Endocrine journal
(Endocr J)
Vol. 48
Issue 1
Pg. 63-9
(Feb 2001)
ISSN: 0918-8959 [Print] Japan |
PMID | 11403104
(Publication Type: Journal Article)
|
Chemical References |
- Antithyroid Agents
- Alkaline Phosphatase
- Calcifediol
- Calcium
|
Topics |
- Adolescent
- Adult
- Alkaline Phosphatase
(blood)
- Antithyroid Agents
(therapeutic use)
- Calcifediol
(blood)
- Calcium
(blood)
- Child
- Female
- Graves Disease
(blood, complications, drug therapy)
- Humans
- Japan
(epidemiology)
- Male
- Middle Aged
- Seasons
- Sex Characteristics
- Vitamin D Deficiency
(complications, epidemiology)
|